TY - JOUR
T1 - Absence of detectable HIV-1 viremia after treatment cessation in an infant
AU - Persaud, Deborah
AU - Gay, Hannah
AU - Ziemniak, Carrie
AU - Chen, Ya Hui
AU - Piatak, Michael
AU - Chun, Tae Wook
AU - Strain, Matthew
AU - Richman, Douglas
AU - Luzuriaga, Katherine
PY - 2013
Y1 - 2013
N2 - An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.
AB - An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.
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U2 - 10.1056/NEJMoa1302976
DO - 10.1056/NEJMoa1302976
M3 - Article
C2 - 24152233
AN - SCOPUS:84887028999
SN - 0028-4793
VL - 369
SP - 1828
EP - 1835
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 19
ER -