Absence of detectable HIV-1 viremia after treatment cessation in an infant

Deborah Persaud, Hannah Gay, Carrie Ziemniak, Ya Hui Chen, Michael Piatak, Tae Wook Chun, Matthew Strain, Douglas Richman, Katherine Luzuriaga

Research output: Contribution to journalArticle

Abstract

An infant born to a woman with human immunodeficiency virus type 1 (HIV-1) infection began receiving antiretroviral therapy (ART) 30 hours after birth owing to high-risk exposure. ART was continued when detection of HIV-1 DNA and RNA on repeat testing met the standard diagnostic criteria for infection. After therapy was discontinued (when the child was 18 months of age), levels of plasma HIV-1 RNA, proviral DNA in peripheral-blood mononuclear cells, and HIV-1 antibodies, as assessed by means of clinical assays, remained undetectable in the child through 30 months of age. This case suggests that very early ART in infants may alter the establishment and long-term persistence of HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)1828-1835
Number of pages8
JournalNew England Journal of Medicine
Volume369
Issue number19
DOIs
StatePublished - 2013

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Withholding Treatment
Viremia
HIV-1
Virus Diseases
RNA
DNA
Secondary Prevention
Blood Cells
Therapeutics
Parturition
Antibodies
Infection

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Persaud, D., Gay, H., Ziemniak, C., Chen, Y. H., Piatak, M., Chun, T. W., ... Luzuriaga, K. (2013). Absence of detectable HIV-1 viremia after treatment cessation in an infant. New England Journal of Medicine, 369(19), 1828-1835. https://doi.org/10.1056/NEJMoa1302976

Absence of detectable HIV-1 viremia after treatment cessation in an infant. / Persaud, Deborah; Gay, Hannah; Ziemniak, Carrie; Chen, Ya Hui; Piatak, Michael; Chun, Tae Wook; Strain, Matthew; Richman, Douglas; Luzuriaga, Katherine.

In: New England Journal of Medicine, Vol. 369, No. 19, 2013, p. 1828-1835.

Research output: Contribution to journalArticle

Persaud, D, Gay, H, Ziemniak, C, Chen, YH, Piatak, M, Chun, TW, Strain, M, Richman, D & Luzuriaga, K 2013, 'Absence of detectable HIV-1 viremia after treatment cessation in an infant', New England Journal of Medicine, vol. 369, no. 19, pp. 1828-1835. https://doi.org/10.1056/NEJMoa1302976
Persaud, Deborah ; Gay, Hannah ; Ziemniak, Carrie ; Chen, Ya Hui ; Piatak, Michael ; Chun, Tae Wook ; Strain, Matthew ; Richman, Douglas ; Luzuriaga, Katherine. / Absence of detectable HIV-1 viremia after treatment cessation in an infant. In: New England Journal of Medicine. 2013 ; Vol. 369, No. 19. pp. 1828-1835.
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