Absence of clonality of Campylobacter jejuni in serotypes other than HS: 19 associated with Guillain-Barré syndrome and gastroenteritis

J. Engberg, I. Nachamkin, V. Fussing, G. M. McKhann, J. W. Griffin, J. C. Piffaretti, E. M. Nielsen, P. Gerner-Smidt

Research output: Contribution to journalArticle

Abstract

Guillain-Barré syndrome (GBS) is recognized as a complication that occurs after Campylobacter infection. Certain Penner serotypes, such as HS:19, are linked particularly to GBS in some parts of the world, and there is good evidence for restricted genetic diversity in these isolates. However, GBS also occurs after Campylobacter infection due to other serotypes. Therefore, we asked whether Campylobacter jejuni non-HS:19 serotypes associated with GBS have a clonal structure and differ from strains isolated from patients with Campylobacter gastroenteritis. A worldwide selected population of C. jejuni non-HS:19 strains associated with GBS and gastroenteritis was analyzed by use of multilocus enzyme electrophoresis, automated ribotyping, pulsed-field gel electrophoresis, and flagellin gene typing. The results show that these isolates represent a heterogenic population and do not constitute a unique population across serotypes. No epidemiologic marker for GBS-associated strains was identified.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalJournal of Infectious Diseases
Volume184
Issue number2
DOIs
StatePublished - Jul 15 2001

Fingerprint

Campylobacter jejuni
Gastroenteritis
Campylobacter Infections
Population
Ribotyping
Flagellin
Campylobacter
Pulsed Field Gel Electrophoresis
Electrophoresis
Serogroup
Enzymes
Genes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Engberg, J., Nachamkin, I., Fussing, V., McKhann, G. M., Griffin, J. W., Piffaretti, J. C., ... Gerner-Smidt, P. (2001). Absence of clonality of Campylobacter jejuni in serotypes other than HS: 19 associated with Guillain-Barré syndrome and gastroenteritis. Journal of Infectious Diseases, 184(2), 215-220. https://doi.org/10.1086/322010

Absence of clonality of Campylobacter jejuni in serotypes other than HS : 19 associated with Guillain-Barré syndrome and gastroenteritis. / Engberg, J.; Nachamkin, I.; Fussing, V.; McKhann, G. M.; Griffin, J. W.; Piffaretti, J. C.; Nielsen, E. M.; Gerner-Smidt, P.

In: Journal of Infectious Diseases, Vol. 184, No. 2, 15.07.2001, p. 215-220.

Research output: Contribution to journalArticle

Engberg, J, Nachamkin, I, Fussing, V, McKhann, GM, Griffin, JW, Piffaretti, JC, Nielsen, EM & Gerner-Smidt, P 2001, 'Absence of clonality of Campylobacter jejuni in serotypes other than HS: 19 associated with Guillain-Barré syndrome and gastroenteritis', Journal of Infectious Diseases, vol. 184, no. 2, pp. 215-220. https://doi.org/10.1086/322010
Engberg, J. ; Nachamkin, I. ; Fussing, V. ; McKhann, G. M. ; Griffin, J. W. ; Piffaretti, J. C. ; Nielsen, E. M. ; Gerner-Smidt, P. / Absence of clonality of Campylobacter jejuni in serotypes other than HS : 19 associated with Guillain-Barré syndrome and gastroenteritis. In: Journal of Infectious Diseases. 2001 ; Vol. 184, No. 2. pp. 215-220.
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