Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression

Jackson Souza-Menezes, Marcelo M. Morales, Deepali N. Tukaye, Sandra E. Guggino, William B Guggino

Research output: Contribution to journalArticle

Abstract

Glycosuria is one of the well-documented characteristics in ClC-5 knockout (KO) mice and patients with Dent's disease. However, the underlying pathophysiology of its occurrence is unknown. In this study, we have compared ClC-5 KO mice with age and gender matched wild-type (WT) control mice to investigate if the underlying cause of manifested glycosuria is an impairment of glucose homeostasis and/or an alteration in expression levels of proximal tubule (PT) glucose transporters. We observed that, the blood glucose concentration (n=12, p

Original languageEnglish (US)
Pages (from-to)455-464
Number of pages10
JournalCellular Physiology and Biochemistry
Volume20
Issue number5
DOIs
Publication statusPublished - 2007

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Keywords

  • ClC-5
  • Glucose homeostasis
  • Glucose transporters and insulin
  • Megalin
  • Proximal tubule

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

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