Absence of acute cocaine interactions with the MAO-B inhibitor selegiline

Kathleen A. Haberny; Sharon L. Walsh; David H. Ginn; Jeffery N. Wilkins; Jane E. Garner; David Setoda; George E. Bigelow

doi:10.1016/0376-8716(95)01137-N

Absence of acute cocaine interactions with the MAO-B inhibitor selegiline

Kathleen A. Haberny, Sharon L. Walsh, David H. Ginn, Jeffery N. Wilkins, Jane E. Garner, David Setoda, George E. Bigelow

School of Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Selegiline, an irreversible monoamine oxidase-B (MAO-B) inhibitor, is under investigation as a treatment for cocaine relapse prevention. To evaluate its safety, human volunteers (n = 5) received intravenous cocaine (0, 20 and 40 mg, 1 h apart) following treatment with placebo or selegiline (10 mg, p.o.). Cocaine increased heart rate, blood pressure, pupil diameter and subjective indices of euphoria and craving. Selegiline produced no measurable effects, except for miosis, and did not alter the effects of cocaine. These data suggest that selegiline may be safely administered in combination with cocaine, and that selegiline is unlikely to increase reinforcing effects of cocaine.

Original language	English (US)
Pages (from-to)	55-62
Number of pages	8
Journal	Drug and alcohol dependence
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/0376-8716(95)01137-N
State	Published - Jul 1995

Keywords

Cardiovascular
Cocaine
Safety
Selegiline
Subjective
l-Deprenyl

ASJC Scopus subject areas

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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10.1016/0376-8716(95)01137-N

Cite this

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abstract = "Selegiline, an irreversible monoamine oxidase-B (MAO-B) inhibitor, is under investigation as a treatment for cocaine relapse prevention. To evaluate its safety, human volunteers (n = 5) received intravenous cocaine (0, 20 and 40 mg, 1 h apart) following treatment with placebo or selegiline (10 mg, p.o.). Cocaine increased heart rate, blood pressure, pupil diameter and subjective indices of euphoria and craving. Selegiline produced no measurable effects, except for miosis, and did not alter the effects of cocaine. These data suggest that selegiline may be safely administered in combination with cocaine, and that selegiline is unlikely to increase reinforcing effects of cocaine.",

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AU - Haberny, Kathleen A.

AU - Walsh, Sharon L.

AU - Ginn, David H.

AU - Wilkins, Jeffery N.

AU - Garner, Jane E.

AU - Setoda, David

AU - Bigelow, George E.

PY - 1995/7

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AB - Selegiline, an irreversible monoamine oxidase-B (MAO-B) inhibitor, is under investigation as a treatment for cocaine relapse prevention. To evaluate its safety, human volunteers (n = 5) received intravenous cocaine (0, 20 and 40 mg, 1 h apart) following treatment with placebo or selegiline (10 mg, p.o.). Cocaine increased heart rate, blood pressure, pupil diameter and subjective indices of euphoria and craving. Selegiline produced no measurable effects, except for miosis, and did not alter the effects of cocaine. These data suggest that selegiline may be safely administered in combination with cocaine, and that selegiline is unlikely to increase reinforcing effects of cocaine.

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KW - Cocaine

KW - Safety

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KW - Subjective

KW - l-Deprenyl

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Absence of acute cocaine interactions with the MAO-B inhibitor selegiline

Abstract

Keywords

ASJC Scopus subject areas

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