ABO-incompatible transplantation: Less may be more

Robert A. Montgomery, Jayme E. Locke

Research output: Contribution to journalArticle

Abstract

Many have reported success with ABO-incompatible kidney transplantation using B-cell ablative therapies such as anti-CD20 and splenectomy. However, splenectomy and anti-CD20 is associated with an increased risk of infection. We show how ABO-incompatible kidney transplants can be accomplished with a low risk of antibody-mediated rejection and graft loss using plasmapheresis preconditioning, low-dose intravenous immunoglobulin, and standard maintenance immunosuppression. The mean follow up for our cohort of 53 patients is 2 years. The mean creatinine clearance at 1 and 3 years is 58 mL/min and 63 mL/min, predicting excellent long-term function. Only long-term follow up of these patients will render definitive answers, however, these data demonstrate that ABO-incompatible kidney transplantation increases the donor pool by providing live donor kidneys that function promptly with minimal risk of early loss. This can be accomplished with a modest, brief escalation of immunosuppression and at a lower cost to the health care system than maintaining the patient on dialysis.

Original languageEnglish (US)
JournalTransplantation
Volume84
Issue number12 S SUPPL.
DOIs
StatePublished - Dec 2007

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Transplantation
Splenectomy
Kidney Transplantation
Immunosuppression
Tissue Donors
Kidney
Plasmapheresis
Intravenous Immunoglobulins
Graft Rejection
Cell- and Tissue-Based Therapy
Dialysis
Creatinine
B-Lymphocytes
Maintenance
Delivery of Health Care
Transplants
Costs and Cost Analysis
Antibodies
Infection

Keywords

  • ABO-incompatible
  • B-cell depletion
  • Immunosuppression
  • Kidney
  • Transplantation

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

ABO-incompatible transplantation : Less may be more. / Montgomery, Robert A.; Locke, Jayme E.

In: Transplantation, Vol. 84, No. 12 S SUPPL., 12.2007.

Research output: Contribution to journalArticle

Montgomery, Robert A. ; Locke, Jayme E. / ABO-incompatible transplantation : Less may be more. In: Transplantation. 2007 ; Vol. 84, No. 12 S SUPPL.
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