ABO Blood Groups and Cholera: New Observations on Specificity of Risk and Modification of Vaccine Efficacy

John D. Clemens; David A. Sack; Jeffrey R. Harris; J. Chakraborty; M. R. Khan; S. Huda; Faruque Ahmed; Joe Gomes; M. R. Rao; Ann Mari Svennerholm; Jan Holmgren

doi:10.1093/infdis/159.4.770

ABO Blood Groups and Cholera: New Observations on Specificity of Risk and Modification of Vaccine Efficacy

John D. Clemens, David A. Sack, Jeffrey R. Harris, J. Chakraborty, M. R. Khan, S. Huda, Faruque Ahmed, Joe Gomes, M. R. Rao, Ann Mari Svennerholm, Jan Holmgren

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

Several studies have documented an association between ABO blood groups and the risk of cholera [1-4J. The biologic basis for this association, however, has remained elusive despite attempts to identify ABO-related host characteristics that might influence the pathophysiologic sequence of cholera [4]. The association of ABO blood groups and cholera would have considerable practical importance for the control of cholera if ABO blood groups modified the protective efficacy of vaccines against cholera. We evaluated ABO groups as related to the risk of cholera and to cholera vaccine efficacy in the first 2 y of follow-up of a large-scalerandomized, double-blinded field trial of killed oral cholera vaccines in rural Bangladesh.

Original language	English (US)
Pages (from-to)	770-773
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	159
Issue number	4
DOIs	https://doi.org/10.1093/infdis/159.4.770
State	Published - Apr 1989

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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@article{a7b693dbe2f84021af4b63356ad6dee4,

title = "ABO Blood Groups and Cholera: New Observations on Specificity of Risk and Modification of Vaccine Efficacy",

abstract = "Several studies have documented an association between ABO blood groups and the risk of cholera [1-4J. The biologic basis for this association, however, has remained elusive despite attempts to identify ABO-related host characteristics that might influence the pathophysiologic sequence of cholera [4]. The association of ABO blood groups and cholera would have considerable practical importance for the control of cholera if ABO blood groups modified the protective efficacy of vaccines against cholera. We evaluated ABO groups as related to the risk of cholera and to cholera vaccine efficacy in the first 2 y of follow-up of a large-scalerandomized, double-blinded field trial of killed oral cholera vaccines in rural Bangladesh.",

author = "Clemens, {John D.} and Sack, {David A.} and Harris, {Jeffrey R.} and J. Chakraborty and Khan, {M. R.} and S. Huda and Faruque Ahmed and Joe Gomes and Rao, {M. R.} and Svennerholm, {Ann Mari} and Jan Holmgren",

note = "Funding Information: This work was supported by the United States Agency for International Development, the government of Japan, the Swedish Agency for Research Cooperation with Developing Countries, and the World Health Organization.",

year = "1989",

month = apr,

doi = "10.1093/infdis/159.4.770",

language = "English (US)",

volume = "159",

pages = "770--773",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

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TY - JOUR

T1 - ABO Blood Groups and Cholera

T2 - New Observations on Specificity of Risk and Modification of Vaccine Efficacy

AU - Clemens, John D.

AU - Sack, David A.

AU - Harris, Jeffrey R.

AU - Chakraborty, J.

AU - Khan, M. R.

AU - Huda, S.

AU - Ahmed, Faruque

AU - Gomes, Joe

AU - Rao, M. R.

AU - Svennerholm, Ann Mari

AU - Holmgren, Jan

N1 - Funding Information: This work was supported by the United States Agency for International Development, the government of Japan, the Swedish Agency for Research Cooperation with Developing Countries, and the World Health Organization.

PY - 1989/4

Y1 - 1989/4

N2 - Several studies have documented an association between ABO blood groups and the risk of cholera [1-4J. The biologic basis for this association, however, has remained elusive despite attempts to identify ABO-related host characteristics that might influence the pathophysiologic sequence of cholera [4]. The association of ABO blood groups and cholera would have considerable practical importance for the control of cholera if ABO blood groups modified the protective efficacy of vaccines against cholera. We evaluated ABO groups as related to the risk of cholera and to cholera vaccine efficacy in the first 2 y of follow-up of a large-scalerandomized, double-blinded field trial of killed oral cholera vaccines in rural Bangladesh.

AB - Several studies have documented an association between ABO blood groups and the risk of cholera [1-4J. The biologic basis for this association, however, has remained elusive despite attempts to identify ABO-related host characteristics that might influence the pathophysiologic sequence of cholera [4]. The association of ABO blood groups and cholera would have considerable practical importance for the control of cholera if ABO blood groups modified the protective efficacy of vaccines against cholera. We evaluated ABO groups as related to the risk of cholera and to cholera vaccine efficacy in the first 2 y of follow-up of a large-scalerandomized, double-blinded field trial of killed oral cholera vaccines in rural Bangladesh.

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JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

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ABO Blood Groups and Cholera: New Observations on Specificity of Risk and Modification of Vaccine Efficacy

Abstract

ASJC Scopus subject areas

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