ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

Elizabeth M. Poole, Margaret A. Gates, Brigit A. High, Stephen J. Chanock, Daniel W. Cramer, Julie M. Cunningham, Brooke L. Fridley, Simon A. Gayther, Ellen L. Goode, Edwin S. Iversen, Jolanta Lissowska, Rachel T Palmieri Weber, Paul D P Pharoah, Catherine M. Phelan, Susan J. Ramus, Joellen M. Schildkraut, Rebecca Sutphen, Ya Yu Tsai, Jonathan Tyrer, Robert A. VierkantNicolas Wentzensen, Hannah P. Yang, Kathryn L. Terry, Shelley S. Tworoger

Research output: Contribution to journalArticle

Abstract

Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in theOvarianCancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI:0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.

Original languageEnglish (US)
Pages (from-to)1805-1810
Number of pages6
JournalCancer Causes and Control
Volume23
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

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Blood Group Antigens
Ovarian Neoplasms
Single Nucleotide Polymorphism
Meta-Analysis
Logistic Models
Odds Ratio
Ovarian epithelial cancer
Confidence Intervals

Keywords

  • ABO blood group
  • Genetic epidemiology
  • Ovarian cancer
  • Ovarian Cancer Association Consortium (OCAC)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Poole, E. M., Gates, M. A., High, B. A., Chanock, S. J., Cramer, D. W., Cunningham, J. M., ... Tworoger, S. S. (2012). ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium. Cancer Causes and Control, 23(11), 1805-1810. https://doi.org/10.1007/s10552-012-0059-y

ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium. / Poole, Elizabeth M.; Gates, Margaret A.; High, Brigit A.; Chanock, Stephen J.; Cramer, Daniel W.; Cunningham, Julie M.; Fridley, Brooke L.; Gayther, Simon A.; Goode, Ellen L.; Iversen, Edwin S.; Lissowska, Jolanta; Weber, Rachel T Palmieri; Pharoah, Paul D P; Phelan, Catherine M.; Ramus, Susan J.; Schildkraut, Joellen M.; Sutphen, Rebecca; Tsai, Ya Yu; Tyrer, Jonathan; Vierkant, Robert A.; Wentzensen, Nicolas; Yang, Hannah P.; Terry, Kathryn L.; Tworoger, Shelley S.

In: Cancer Causes and Control, Vol. 23, No. 11, 11.2012, p. 1805-1810.

Research output: Contribution to journalArticle

Poole, EM, Gates, MA, High, BA, Chanock, SJ, Cramer, DW, Cunningham, JM, Fridley, BL, Gayther, SA, Goode, EL, Iversen, ES, Lissowska, J, Weber, RTP, Pharoah, PDP, Phelan, CM, Ramus, SJ, Schildkraut, JM, Sutphen, R, Tsai, YY, Tyrer, J, Vierkant, RA, Wentzensen, N, Yang, HP, Terry, KL & Tworoger, SS 2012, 'ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium', Cancer Causes and Control, vol. 23, no. 11, pp. 1805-1810. https://doi.org/10.1007/s10552-012-0059-y
Poole, Elizabeth M. ; Gates, Margaret A. ; High, Brigit A. ; Chanock, Stephen J. ; Cramer, Daniel W. ; Cunningham, Julie M. ; Fridley, Brooke L. ; Gayther, Simon A. ; Goode, Ellen L. ; Iversen, Edwin S. ; Lissowska, Jolanta ; Weber, Rachel T Palmieri ; Pharoah, Paul D P ; Phelan, Catherine M. ; Ramus, Susan J. ; Schildkraut, Joellen M. ; Sutphen, Rebecca ; Tsai, Ya Yu ; Tyrer, Jonathan ; Vierkant, Robert A. ; Wentzensen, Nicolas ; Yang, Hannah P. ; Terry, Kathryn L. ; Tworoger, Shelley S. / ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium. In: Cancer Causes and Control. 2012 ; Vol. 23, No. 11. pp. 1805-1810.
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abstract = "Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in theOvarianCancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 {\%} confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 {\%} CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 {\%} CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 {\%} CI:0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.",
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T1 - ABO blood group and risk of epithelial ovarian cancer within the Ovarian Cancer Association Consortium

AU - Poole, Elizabeth M.

AU - Gates, Margaret A.

AU - High, Brigit A.

AU - Chanock, Stephen J.

AU - Cramer, Daniel W.

AU - Cunningham, Julie M.

AU - Fridley, Brooke L.

AU - Gayther, Simon A.

AU - Goode, Ellen L.

AU - Iversen, Edwin S.

AU - Lissowska, Jolanta

AU - Weber, Rachel T Palmieri

AU - Pharoah, Paul D P

AU - Phelan, Catherine M.

AU - Ramus, Susan J.

AU - Schildkraut, Joellen M.

AU - Sutphen, Rebecca

AU - Tsai, Ya Yu

AU - Tyrer, Jonathan

AU - Vierkant, Robert A.

AU - Wentzensen, Nicolas

AU - Yang, Hannah P.

AU - Terry, Kathryn L.

AU - Tworoger, Shelley S.

PY - 2012/11

Y1 - 2012/11

N2 - Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in theOvarianCancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI:0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.

AB - Purpose Previous studies have examined the association between ABO blood group and ovarian cancer risk, with inconclusive results. Methods In eight studies participating in theOvarianCancer Association Consortium, we determined ABO blood groups and diplotypes by genotyping 3 SNPs in the ABO locus. Odds ratios and 95 % confidence intervals were calculated in each study using logistic regression; individual study results were combined using random effects meta-analysis. Results Compared to blood group O, the A blood group was associated with a modestly increased ovarian cancer risk: (OR: 1.09; 95 % CI: 1.01-1.18; p = 0.03). In diplotype analysis, the AO, but not the AA diplotype, was associated with increased risk (AO: OR: 1.11; 95 % CI: 1.01-1.22; p = 0.03; AA: OR: 1.03; 95 % CI:0.87-1.21; p = 0.76). Neither AB nor the B blood groups were associated with risk. Results were similar across ovarian cancer histologic subtypes. Conclusion Consistent with most previous reports, the A blood type was associated modestly with increased ovarian cancer risk in this large analysis of multiple studies of ovarian cancer. Future studies investigating potential biologic mechanisms are warranted.

KW - ABO blood group

KW - Genetic epidemiology

KW - Ovarian cancer

KW - Ovarian Cancer Association Consortium (OCAC)

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