Abnormalities in water homeostasis in small cell anaplastic lung cancer

R. L. Comis, Myron Miller, S. J. Ginsberg

Research output: Contribution to journalArticle

Abstract

Forty-one patients with newly diagnosed small cell anaplastic lung cancer were evaluated for abnormalities in water homeostasis. Each patient underwent a standard water load (SWL) test. Overall, 68% had abnormalities in the SWL test. Abnormalities were found in 47% of the patients with carcinoma clinically limited to one hemithorax and in 86% of the patients with more extensive carcinoma. The determination of urinary antidiuretic hormone levels was available for 27 patients. Abnormally elevated levels were found in 44% of those patients. Forty-six percent of patients had clinically detectable syndrome of the inappropriate secretion of antidiuretic hormone (SIADH); in 12% of patients water restriction was necessary. The incidence of detectable abnormalities in water homeostasis in this study was higher than has been previously recognized. The SWL test is a sensitive and useful means of determining the presence of impaired water handling in patients with small cell carcinoma of the lung.

Original languageEnglish (US)
Pages (from-to)2414-2421
Number of pages8
JournalCancer
Volume45
Issue number9
StatePublished - 1980
Externally publishedYes

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Small Cell Lung Carcinoma
Homeostasis
Water
Inappropriate ADH Syndrome
Moving and Lifting Patients
Carcinoma
Vasopressins
Incidence

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Comis, R. L., Miller, M., & Ginsberg, S. J. (1980). Abnormalities in water homeostasis in small cell anaplastic lung cancer. Cancer, 45(9), 2414-2421.

Abnormalities in water homeostasis in small cell anaplastic lung cancer. / Comis, R. L.; Miller, Myron; Ginsberg, S. J.

In: Cancer, Vol. 45, No. 9, 1980, p. 2414-2421.

Research output: Contribution to journalArticle

Comis, RL, Miller, M & Ginsberg, SJ 1980, 'Abnormalities in water homeostasis in small cell anaplastic lung cancer', Cancer, vol. 45, no. 9, pp. 2414-2421.
Comis, R. L. ; Miller, Myron ; Ginsberg, S. J. / Abnormalities in water homeostasis in small cell anaplastic lung cancer. In: Cancer. 1980 ; Vol. 45, No. 9. pp. 2414-2421.
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