Abstract
Forty‐one patients with newly diagnosed small cell anaplastic lung cancer were evaluated for abnormalities in water homeostasis. Each patient underwent a standard water load (SWL) test. Overall, 68% had abnormalities in the SWL test. Abnormalities were found in 47% of the patients with carcinoma clinically limited to one hemithorax and in 86% of the patients with more extensive carcinoma. The determination of urinary antidiuretic hormone levels was available for 27 patients. Abnormally elevated levels were found in 44% of those patients. Forty‐six percent of patients had clinically detectable syndrome of the inappropriate secretion of antidiuretic hormone (SIADH); in 12% of patients water restriction was necessary. The incidence of detectable abnormalities in water homeostasis in this study was higher than has been previously recognized. The SWL test is a sensitive and useful means of determining the presence of impaired water handling in patients with small cell carcinoma of the lung.
Original language | English (US) |
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Pages (from-to) | 2414-2421 |
Number of pages | 8 |
Journal | Cancer |
Volume | 45 |
Issue number | 9 |
DOIs | |
State | Published - May 1 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research