TY - JOUR
T1 - Abnormalities in Parathyroid Hormone Secretion and 1,25-Dihydroxyvitamin D3 Formation in Women with Osteoporosis
AU - Franz, Kay B.
AU - Silverberg, Shonni J.
AU - Shane, Elizabeth
AU - Cruz, Luz de la
AU - Segre, Grao V.
AU - Clemens, Thomas L.
AU - Bilezikian, John P.
PY - 1989/6/22
Y1 - 1989/6/22
N2 - To the Editor: Silverberg et al. (Feb. 2 issue) 1 provide important information on abnormalities of parathyroid hormone (PTH) secretion and 1,25-dihydroxyvitamin D3 (1,25(OH)2D) formation in osteoporosis. Changes in the secretion of PTH were attributed to natural aging and the disease process of osteoporosis. However, the results could be explained on the basis of chronic or severe magnesium deficiencies. Magnesium influences PTH secretion2 3 4 and both renal and skeletal sensitivity to PTH.4,5 In rats, magnesium deficiency has resulted in osteoporosis and the cessation of bone growth.6,7 In the progression from a normal magnesium nutritional status to a severe deficiency,.
AB - To the Editor: Silverberg et al. (Feb. 2 issue) 1 provide important information on abnormalities of parathyroid hormone (PTH) secretion and 1,25-dihydroxyvitamin D3 (1,25(OH)2D) formation in osteoporosis. Changes in the secretion of PTH were attributed to natural aging and the disease process of osteoporosis. However, the results could be explained on the basis of chronic or severe magnesium deficiencies. Magnesium influences PTH secretion2 3 4 and both renal and skeletal sensitivity to PTH.4,5 In rats, magnesium deficiency has resulted in osteoporosis and the cessation of bone growth.6,7 In the progression from a normal magnesium nutritional status to a severe deficiency,.
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U2 - 10.1056/NEJM198906223202515
DO - 10.1056/NEJM198906223202515
M3 - Letter
C2 - 2725625
AN - SCOPUS:0024381450
SN - 0028-4793
VL - 320
SP - 1697
EP - 1698
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 25
ER -