Abnormalities in Parathyroid Hormone Secretion and 1,25-Dihydroxyvitamin D3 Formation in Women with Osteoporosis

Kay B. Franz, Shonni J. Silverberg, Elizabeth Shane, Luz de la Cruz, Grao V. Segre, Thomas L. Clemens, John P. Bilezikian

Research output: Contribution to journalLetterpeer-review


To the Editor: Silverberg et al. (Feb. 2 issue) 1 provide important information on abnormalities of parathyroid hormone (PTH) secretion and 1,25-dihydroxyvitamin D3 (1,25(OH)2D) formation in osteoporosis. Changes in the secretion of PTH were attributed to natural aging and the disease process of osteoporosis. However, the results could be explained on the basis of chronic or severe magnesium deficiencies. Magnesium influences PTH secretion2 3 4 and both renal and skeletal sensitivity to PTH.4,5 In rats, magnesium deficiency has resulted in osteoporosis and the cessation of bone growth.6,7 In the progression from a normal magnesium nutritional status to a severe deficiency,.

Original languageEnglish (US)
Pages (from-to)1697-1698
Number of pages2
JournalNew England Journal of Medicine
Issue number25
StatePublished - Jun 22 1989
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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