Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis

S. J. Silverberg, E. Shane, L. De La Cruz, G. V. Segre, Thomas Clemens, J. P. Bilezikian

Research output: Contribution to journalArticle

Abstract

We investigated the parathyroid hormone-1,25-dihydroxyvitamin D3 (1,25(OH)2D) axis in osteoporosis by administering phosphate to 8 postmenopausal women with osteoporosis (49 to 78 years old) and to 10 normal women matched for age (50 to 74 years). All subjects responded with a similar increase in the serum phosphorus concentration (women with osteoporosis, 1.15±0.06 to 1.79±0.09 mmol per liter; controls, 1.14±0.05 to 1.73±0.08 mmol per liter) and a fall in the ionized calcium concentration (women with osteoporosis, 1.12±0.03 to 1.06±0.03 mmol per liter; controls, 1.17±0.01 to 1.11±0.02 mmol per liter). Parathyroid hormone levels rose 2.5-fold in the control group (15.4±2.2 to 37.9±6.1 pg per milliliter) but increased by only 43 percent in the group with osteoporosis (14.8±2.8 to 21.2±4.1 pg per milliliter), an increase similar to that previously reported in young normal subjects (53 percent). In healthy older and younger subjects, the levels of 1,25(OH)2D did not change; in the subjects with osteoporosis, however, they decreased significantly (50 percent). We conclude that older women require a greater parathyroid hormone stimulus than younger women to maintain vitamin D homeostasis, because of an age-related decline in the formation of 1,25(OH)2D in respose to parathyroid hormone, and that in osteoporosis the age-appropriate parathyroid hormone response to the same hypocalcemic signal is diminished. Our results are consistent with the presence of an abnormality in parathyroid hormone secretory function in osteoporosis in addition to the universal decline in 1,25(OH)2D responsiveness associated with aging.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalNew England Journal of Medicine
Volume320
Issue number5
StatePublished - 1989
Externally publishedYes

Fingerprint

Calcitriol
Parathyroid Hormone
Osteoporosis
Vitamin D
Phosphorus
Homeostasis
Phosphates
Calcium
Control Groups
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Silverberg, S. J., Shane, E., De La Cruz, L., Segre, G. V., Clemens, T., & Bilezikian, J. P. (1989). Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis. New England Journal of Medicine, 320(5), 277-281.

Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis. / Silverberg, S. J.; Shane, E.; De La Cruz, L.; Segre, G. V.; Clemens, Thomas; Bilezikian, J. P.

In: New England Journal of Medicine, Vol. 320, No. 5, 1989, p. 277-281.

Research output: Contribution to journalArticle

Silverberg, SJ, Shane, E, De La Cruz, L, Segre, GV, Clemens, T & Bilezikian, JP 1989, 'Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis', New England Journal of Medicine, vol. 320, no. 5, pp. 277-281.
Silverberg, S. J. ; Shane, E. ; De La Cruz, L. ; Segre, G. V. ; Clemens, Thomas ; Bilezikian, J. P. / Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis. In: New England Journal of Medicine. 1989 ; Vol. 320, No. 5. pp. 277-281.
@article{3833e9d4c80a40ffa857acb65bf809fa,
title = "Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis",
abstract = "We investigated the parathyroid hormone-1,25-dihydroxyvitamin D3 (1,25(OH)2D) axis in osteoporosis by administering phosphate to 8 postmenopausal women with osteoporosis (49 to 78 years old) and to 10 normal women matched for age (50 to 74 years). All subjects responded with a similar increase in the serum phosphorus concentration (women with osteoporosis, 1.15±0.06 to 1.79±0.09 mmol per liter; controls, 1.14±0.05 to 1.73±0.08 mmol per liter) and a fall in the ionized calcium concentration (women with osteoporosis, 1.12±0.03 to 1.06±0.03 mmol per liter; controls, 1.17±0.01 to 1.11±0.02 mmol per liter). Parathyroid hormone levels rose 2.5-fold in the control group (15.4±2.2 to 37.9±6.1 pg per milliliter) but increased by only 43 percent in the group with osteoporosis (14.8±2.8 to 21.2±4.1 pg per milliliter), an increase similar to that previously reported in young normal subjects (53 percent). In healthy older and younger subjects, the levels of 1,25(OH)2D did not change; in the subjects with osteoporosis, however, they decreased significantly (50 percent). We conclude that older women require a greater parathyroid hormone stimulus than younger women to maintain vitamin D homeostasis, because of an age-related decline in the formation of 1,25(OH)2D in respose to parathyroid hormone, and that in osteoporosis the age-appropriate parathyroid hormone response to the same hypocalcemic signal is diminished. Our results are consistent with the presence of an abnormality in parathyroid hormone secretory function in osteoporosis in addition to the universal decline in 1,25(OH)2D responsiveness associated with aging.",
author = "Silverberg, {S. J.} and E. Shane and {De La Cruz}, L. and Segre, {G. V.} and Thomas Clemens and Bilezikian, {J. P.}",
year = "1989",
language = "English (US)",
volume = "320",
pages = "277--281",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "5",

}

TY - JOUR

T1 - Abnormalities in parathyroid hormone secretion and 1,25-dihydroxyvitamin D3 formation in women with osteoporosis

AU - Silverberg, S. J.

AU - Shane, E.

AU - De La Cruz, L.

AU - Segre, G. V.

AU - Clemens, Thomas

AU - Bilezikian, J. P.

PY - 1989

Y1 - 1989

N2 - We investigated the parathyroid hormone-1,25-dihydroxyvitamin D3 (1,25(OH)2D) axis in osteoporosis by administering phosphate to 8 postmenopausal women with osteoporosis (49 to 78 years old) and to 10 normal women matched for age (50 to 74 years). All subjects responded with a similar increase in the serum phosphorus concentration (women with osteoporosis, 1.15±0.06 to 1.79±0.09 mmol per liter; controls, 1.14±0.05 to 1.73±0.08 mmol per liter) and a fall in the ionized calcium concentration (women with osteoporosis, 1.12±0.03 to 1.06±0.03 mmol per liter; controls, 1.17±0.01 to 1.11±0.02 mmol per liter). Parathyroid hormone levels rose 2.5-fold in the control group (15.4±2.2 to 37.9±6.1 pg per milliliter) but increased by only 43 percent in the group with osteoporosis (14.8±2.8 to 21.2±4.1 pg per milliliter), an increase similar to that previously reported in young normal subjects (53 percent). In healthy older and younger subjects, the levels of 1,25(OH)2D did not change; in the subjects with osteoporosis, however, they decreased significantly (50 percent). We conclude that older women require a greater parathyroid hormone stimulus than younger women to maintain vitamin D homeostasis, because of an age-related decline in the formation of 1,25(OH)2D in respose to parathyroid hormone, and that in osteoporosis the age-appropriate parathyroid hormone response to the same hypocalcemic signal is diminished. Our results are consistent with the presence of an abnormality in parathyroid hormone secretory function in osteoporosis in addition to the universal decline in 1,25(OH)2D responsiveness associated with aging.

AB - We investigated the parathyroid hormone-1,25-dihydroxyvitamin D3 (1,25(OH)2D) axis in osteoporosis by administering phosphate to 8 postmenopausal women with osteoporosis (49 to 78 years old) and to 10 normal women matched for age (50 to 74 years). All subjects responded with a similar increase in the serum phosphorus concentration (women with osteoporosis, 1.15±0.06 to 1.79±0.09 mmol per liter; controls, 1.14±0.05 to 1.73±0.08 mmol per liter) and a fall in the ionized calcium concentration (women with osteoporosis, 1.12±0.03 to 1.06±0.03 mmol per liter; controls, 1.17±0.01 to 1.11±0.02 mmol per liter). Parathyroid hormone levels rose 2.5-fold in the control group (15.4±2.2 to 37.9±6.1 pg per milliliter) but increased by only 43 percent in the group with osteoporosis (14.8±2.8 to 21.2±4.1 pg per milliliter), an increase similar to that previously reported in young normal subjects (53 percent). In healthy older and younger subjects, the levels of 1,25(OH)2D did not change; in the subjects with osteoporosis, however, they decreased significantly (50 percent). We conclude that older women require a greater parathyroid hormone stimulus than younger women to maintain vitamin D homeostasis, because of an age-related decline in the formation of 1,25(OH)2D in respose to parathyroid hormone, and that in osteoporosis the age-appropriate parathyroid hormone response to the same hypocalcemic signal is diminished. Our results are consistent with the presence of an abnormality in parathyroid hormone secretory function in osteoporosis in addition to the universal decline in 1,25(OH)2D responsiveness associated with aging.

UR - http://www.scopus.com/inward/record.url?scp=0024548046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024548046&partnerID=8YFLogxK

M3 - Article

C2 - 2911322

AN - SCOPUS:0024548046

VL - 320

SP - 277

EP - 281

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 5

ER -