Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

Christopher J. Earley, J. R. Connor, J. L. Beard, E. A. Malecki, D. K. Epstein, R. P. Allen

Research output: Contribution to journalArticle

Abstract

CSF and serum were obtained from 16 patients with idiopathic restless legs syndrome (RLS) and 8 age-matched healthy control subjects. Patients with RLS had lower CSF ferritin levels (1.11 ± 0.25 ng/mL versus 3.50 ± 0.55 ng/mL; p = 0.0002) and higher CSF transferrin levels (26.4 ± 5.1 mg/L versus 6.71 ± 1.6 mg/L; p = 0.018) compared with control subjects. There was no difference in serum ferritin and transferrin levels between groups. The presence of reduced ferritin and elevated transferrin levels in CSF is indicative of low brain iron in patients with idiopathic RLS.

Original languageEnglish (US)
Pages (from-to)1698-1700
Number of pages3
JournalNeurology
Volume54
Issue number8
DOIs
StatePublished - Apr 25 2000

Keywords

  • CSF
  • Ferritin
  • Iron
  • Restless legs syndrome
  • Transferrin

ASJC Scopus subject areas

  • Clinical Neurology

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