Abnormal thalamocortical network dynamics in migraine

Yiheng Tu, Zening Fu, Fang Zeng, Nasim Maleki, Lei Lan, Zhengjie Li, Joel Park, Georgia Wilson, Yujie Gao, Mailan Liu, Vince Calhoun, Fanrong Liang, Jian Kong

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To investigate the dynamic functional connectivity of thalamocortical networks in interictal migraine patients and whether clinical features are associated with abnormal connectivity. METHODS: We investigated dynamic functional network connectivity (dFNC) of the migraine brain in 89 interictal migraine patients and 70 healthy controls. We focused on the temporal properties of thalamocortical connectivity using sliding window cross-correlation, clustering state analysis, and graph-theory methods. Relationships between clinical symptoms and abnormal dFNC were evaluated using a multivariate linear regression model. RESULTS: Five dFNC brain states were identified to characterize and compare dynamic functional connectivity patterns. We demonstrated that migraineurs spent more time in a strongly interconnected between-network state, but they spent less time in a sparsely connected state. Interestingly, we found that abnormal posterior thalamus (pulvinar nucleus) dFNC with the visual cortex and the precuneus were significantly correlated with headache frequency of migraine. Further topologic measures revealed that migraineurs had significantly lower efficiency of information transfer in both global and local dFNC. CONCLUSION: Our results demonstrated a transient pathologic state with atypical thalamocortical connectivity in migraineurs and extended current findings regarding abnormal thalamocortical networks and dysrhythmia in migraine.

Original languageEnglish (US)
Pages (from-to)e2706-e2716
JournalNeurology
Volume92
Issue number23
DOIs
StatePublished - Jun 4 2019
Externally publishedYes

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Migraine Disorders
Linear Models
Pulvinar
Parietal Lobe
Brain
Visual Cortex
Thalamus
Cluster Analysis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Tu, Y., Fu, Z., Zeng, F., Maleki, N., Lan, L., Li, Z., ... Kong, J. (2019). Abnormal thalamocortical network dynamics in migraine. Neurology, 92(23), e2706-e2716. https://doi.org/10.1212/WNL.0000000000007607

Abnormal thalamocortical network dynamics in migraine. / Tu, Yiheng; Fu, Zening; Zeng, Fang; Maleki, Nasim; Lan, Lei; Li, Zhengjie; Park, Joel; Wilson, Georgia; Gao, Yujie; Liu, Mailan; Calhoun, Vince; Liang, Fanrong; Kong, Jian.

In: Neurology, Vol. 92, No. 23, 04.06.2019, p. e2706-e2716.

Research output: Contribution to journalArticle

Tu, Y, Fu, Z, Zeng, F, Maleki, N, Lan, L, Li, Z, Park, J, Wilson, G, Gao, Y, Liu, M, Calhoun, V, Liang, F & Kong, J 2019, 'Abnormal thalamocortical network dynamics in migraine', Neurology, vol. 92, no. 23, pp. e2706-e2716. https://doi.org/10.1212/WNL.0000000000007607
Tu Y, Fu Z, Zeng F, Maleki N, Lan L, Li Z et al. Abnormal thalamocortical network dynamics in migraine. Neurology. 2019 Jun 4;92(23):e2706-e2716. https://doi.org/10.1212/WNL.0000000000007607
Tu, Yiheng ; Fu, Zening ; Zeng, Fang ; Maleki, Nasim ; Lan, Lei ; Li, Zhengjie ; Park, Joel ; Wilson, Georgia ; Gao, Yujie ; Liu, Mailan ; Calhoun, Vince ; Liang, Fanrong ; Kong, Jian. / Abnormal thalamocortical network dynamics in migraine. In: Neurology. 2019 ; Vol. 92, No. 23. pp. e2706-e2716.
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