Abnormal T-cell subset proportions in vitamin-A-deficient children

Richard David Semba, Keith West, Ph, Alfred Sommer, Diane Griffin, B. J. Ward, D. E. Griffin, R. D. Semba, Alan Leroy Scott, Muhilal, G. Natadisastra

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Abstract

Although vitamin A deficiency in children seems to increase susceptibility to infection and community trials have shown that vitamin A supplementation can reduce childhood mortality from infectious diseases, the underlying biological mechanisms are largely unknown. We conducted a randomised, double-masked, placebo-controlled clinical trial among children in West Java, Indonesia, to determine whether vitamin A deficiency is associated with abnormalities in T-cell subsets and whether vitamin A supplementation affects T-cell subsets. We studied 55 children aged 3-6 years-30 with xerophthalmia and 25 without. Acutely malnourished children (

Original languageEnglish (US)
Pages (from-to)5-8
Number of pages4
JournalThe Lancet
Volume341
Issue number8836
DOIs
Publication statusPublished - Jan 2 1993

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ASJC Scopus subject areas

  • Medicine(all)

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