ABNORMAL RESPONSE OF ŒDEMATOUS PATIENTS TO ALDOSTERONE OR DEOXYCORTONE. / Nelson, Don H.; Thomas August, J.In: The Lancet, Vol. 274, No. 7108, 21.11.1959, p. 883-885.
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TY - JOUR
T1 - ABNORMAL RESPONSE OF ŒDEMATOUS PATIENTS TO ALDOSTERONE OR DEOXYCORTONE
AU - Nelson, Don H.
AU - Thomas August, J.
N1 - Funding Information: Summary Aldosterone or deoxycortone was administered to four oedematous patients with congestive heart-failure, cirr- hosis and ascites, nephrosis, and hypoproteinsemia, and the effects were compared with those in a group of normal subjects or patients with Addison’s disease. Three chief differences were noted: (1) sodium reten- tion was more nearly complete in the oedematous group; (2) in this group there was no secondary " escape " from the renal sodium-retaining effects of the steroid as there was in the normal group; (3) although increased urinary potassium excretion is common in treated normal sub- jects, this was not demonstrable in the oedematous patients. The lack of escape " " from renal sodium retention and the completeness of sodium reabsorption, with failure to excrete greater than normal amounts of potassium, indicate an abnormal response to aldosterone in oedema- tous patients. This work was supported in part by grants from the United States Public Health Service, Bethesda, Maryland (grant A-19 [C8]), and the John A. Hartford Foundation, Inc., New York City. We wish to thank Dr. Robert Gaunt and Dr. C. H. Sullivan, of Ciba Pharmaceutical Products, Inc., for our supply of aldosterone. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1959/11/21
Y1 - 1959/11/21
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U2 - 10.1016/S0140-6736(59)90807-4
DO - 10.1016/S0140-6736(59)90807-4
M3 - Article
C2 - 14426441
AN - SCOPUS:4544373673
VL - 274
SP - 883
EP - 885
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 7108