Objective: To examine the constitutive pattern of cytokine production in patients with polymyositis (PM) and dermatomyositis (DM). Methods: PBMC secreting the type 1 cytokines IL-2 and IFNχ and the type 2 cytokines IL-6 and IL-10 were monitored by ELIspot assay. Results: The frequency of IFNγ-secreting PBMC was reduced 2 - 20 fold in patients with PM and DM when compared to normal controls (p <0.01). This change correlated inversely with disease activity (p <0.01). PM and DM were also characterized by increased numbers of cells secreting IL-10. Patients with DM had fewer IL-2 (p <0.03) and more IL-6 (p <0.006) secreting cells than normal controls or patients with other myopathies. Conclusions: Abnormal patterns of cytokine production characterize patients with PM and DM.
|Original language||English (US)|
|Number of pages||7|
|Journal||Clinical and Experimental Rheumatology|
|State||Published - Sep 1996|
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