Abnormal numbers of cytokine producing cells in patients with polymyositis and dermatomyositis

E. Hagiwara, E. M. Adams, P. H. Plotz, D. M. Klinman

Research output: Contribution to journalArticle

Abstract

Objective: To examine the constitutive pattern of cytokine production in patients with polymyositis (PM) and dermatomyositis (DM). Methods: PBMC secreting the type 1 cytokines IL-2 and IFNχ and the type 2 cytokines IL-6 and IL-10 were monitored by ELIspot assay. Results: The frequency of IFNγ-secreting PBMC was reduced 2 - 20 fold in patients with PM and DM when compared to normal controls (p <0.01). This change correlated inversely with disease activity (p <0.01). PM and DM were also characterized by increased numbers of cells secreting IL-10. Patients with DM had fewer IL-2 (p <0.03) and more IL-6 (p <0.006) secreting cells than normal controls or patients with other myopathies. Conclusions: Abnormal patterns of cytokine production characterize patients with PM and DM.

Original languageEnglish (US)
Pages (from-to)485-491
Number of pages7
JournalClinical and Experimental Rheumatology
Volume14
Issue number5
StatePublished - Sep 1996
Externally publishedYes

Keywords

  • cytokines
  • dermatomyositis
  • polymyositis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Fingerprint Dive into the research topics of 'Abnormal numbers of cytokine producing cells in patients with polymyositis and dermatomyositis'. Together they form a unique fingerprint.

  • Cite this