Abnormal myocardial mechanics in Kawasaki disease: Rapid response to γ- globulin

A. M. Moran, J. W. Newburger, S. P. Sanders, I. A. Parness, Philip J Spevak, J. C. Burns, S. D. Colan

Research output: Contribution to journalArticle

Abstract

Background: The time course and rate of recovery of myocardial dysfunction in association with Kawasaki disease in response to intravenous γ-globulin is unknown and may provide mechanistic clues. Methods and Results: The acute changes in myocardial contractility in 25 patients with Kawasaki disease were evaluated by noninvasive stress-shortening and stress- velocity analysis. Echocardiograms were performed before and then daily for 4 days during which the patients received γ-globulin 1.6 to 2 g/kg. Before treatment, contractility was abnormally low (

Original languageEnglish (US)
Pages (from-to)217-223
Number of pages7
JournalAmerican Heart Journal
Volume139
Issue number2 I
StatePublished - 2000

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Mucocutaneous Lymph Node Syndrome
Globulins
Mechanics
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Moran, A. M., Newburger, J. W., Sanders, S. P., Parness, I. A., Spevak, P. J., Burns, J. C., & Colan, S. D. (2000). Abnormal myocardial mechanics in Kawasaki disease: Rapid response to γ- globulin. American Heart Journal, 139(2 I), 217-223.

Abnormal myocardial mechanics in Kawasaki disease : Rapid response to γ- globulin. / Moran, A. M.; Newburger, J. W.; Sanders, S. P.; Parness, I. A.; Spevak, Philip J; Burns, J. C.; Colan, S. D.

In: American Heart Journal, Vol. 139, No. 2 I, 2000, p. 217-223.

Research output: Contribution to journalArticle

Moran, AM, Newburger, JW, Sanders, SP, Parness, IA, Spevak, PJ, Burns, JC & Colan, SD 2000, 'Abnormal myocardial mechanics in Kawasaki disease: Rapid response to γ- globulin', American Heart Journal, vol. 139, no. 2 I, pp. 217-223.
Moran AM, Newburger JW, Sanders SP, Parness IA, Spevak PJ, Burns JC et al. Abnormal myocardial mechanics in Kawasaki disease: Rapid response to γ- globulin. American Heart Journal. 2000;139(2 I):217-223.
Moran, A. M. ; Newburger, J. W. ; Sanders, S. P. ; Parness, I. A. ; Spevak, Philip J ; Burns, J. C. ; Colan, S. D. / Abnormal myocardial mechanics in Kawasaki disease : Rapid response to γ- globulin. In: American Heart Journal. 2000 ; Vol. 139, No. 2 I. pp. 217-223.
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