Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart

H. Nakayama, T. Morozumi, S. Nanto, T. Shimonagata, T. Ohara, Y. Takano, J. Kotani, T. Watanabe, M. Fujita, M. Nishio, H. Kusuoka, M. Hori, S. Nagata

Research output: Contribution to journalArticle

Abstract

The left ventricle's morphological adaptation to high blood pressure is classified into 4 patterns based on mass and wall thickness. The geometric changes caused by maladaptation to pressure overload possibly relate to progression of contractile dysfunction with abnormal energy metabolism. The present study assessed whether the geometric adaptation of the left ventricle (LV) to high blood pressure relates to changes in myocardial energy metabolism, especially free fatty acid (FFA) utilization. Thirty-five patients with essential hypertension underwent echocardiography and dual isotopes myocardial scintigraphy using iodine-123 labeled 15-p-iodophenyl-3-(R,S)-methylpentadecanoic acid (BMIPP, an analogue of a FFA) and thallium-201 (Tl-201). Systolic (endocardial fractional shortening; %FS) and diastolic indices (the ratio of early to atrial filling waves; E/A) of LV function were also assessed. Quantitative myocardial BMIPP uptake was evaluated by the BMIPP/Tl-201 myocardial uptake ratio (B/T). The subjects were divided into 4 groups based on LV mass and wall thickness: (1) concentric hypertrophy (CH), (2) eccentric hypertrophy (EH), (3) concentric remodeling (CR), and (4) normal geometry (N). The %FS was lower in the EH group than in the other groups. The mitral E/A ratio in the CH group was lowest. B/T was significantly decreased in the EH group compared with the N group (p

Original languageEnglish (US)
Pages (from-to)783-787
Number of pages5
JournalJapanese Circulation Journal
Volume65
Issue number9
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Nonesterified Fatty Acids
Hypertrophy
Heart Ventricles
Thallium
Energy Metabolism
Hypertension
Myocardial Perfusion Imaging
Isotopes
Iodine
Echocardiography
Pressure
Acids
iodofiltic acid

Keywords

  • Energy metabolism
  • Free fatty acids
  • Hypertensive heart
  • Hypertrophy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Nakayama, H., Morozumi, T., Nanto, S., Shimonagata, T., Ohara, T., Takano, Y., ... Nagata, S. (2001). Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart. Japanese Circulation Journal, 65(9), 783-787. https://doi.org/10.1253/jcj.65.783

Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart. / Nakayama, H.; Morozumi, T.; Nanto, S.; Shimonagata, T.; Ohara, T.; Takano, Y.; Kotani, J.; Watanabe, T.; Fujita, M.; Nishio, M.; Kusuoka, H.; Hori, M.; Nagata, S.

In: Japanese Circulation Journal, Vol. 65, No. 9, 2001, p. 783-787.

Research output: Contribution to journalArticle

Nakayama, H, Morozumi, T, Nanto, S, Shimonagata, T, Ohara, T, Takano, Y, Kotani, J, Watanabe, T, Fujita, M, Nishio, M, Kusuoka, H, Hori, M & Nagata, S 2001, 'Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart', Japanese Circulation Journal, vol. 65, no. 9, pp. 783-787. https://doi.org/10.1253/jcj.65.783
Nakayama, H. ; Morozumi, T. ; Nanto, S. ; Shimonagata, T. ; Ohara, T. ; Takano, Y. ; Kotani, J. ; Watanabe, T. ; Fujita, M. ; Nishio, M. ; Kusuoka, H. ; Hori, M. ; Nagata, S. / Abnormal myocardial free fatty acid utilization deteriorates with morphological changes in the hypertensive heart. In: Japanese Circulation Journal. 2001 ; Vol. 65, No. 9. pp. 783-787.
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AU - Ohara, T.

AU - Takano, Y.

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