Abnormal macular pigment distribution in type 2 idiopathic macular telangiectasia

Hans Martin Helb, Peter Charbel Issa, Rob L.P. Van Der Veen, Tos T.J.M. Berendschot, Hendrik P.N. Scholl, Frank G. Holz

Research output: Contribution to journalArticlepeer-review


PURPOSE: To determine the distribution of macular pigment in type 2 idiopathic macular telangiectasia (IMT). METHODS: Twenty-two eyes of 12 patients with type 2 IMT were examined by means of best-corrected visual acuity testing, fundus biomicroscopy, fundus photography, fluorescein angiography, and optical coherence tomography. Macular pigment optical density (MPOD) was assessed using a modified confocal scanning laser ophthalmoscope whereby MPOD was calculated from fundus autofluorescence images acquired at two different excitation wavelengths (488 and 514 nm). The results were verified with a method that provides density maps after digital subtraction of log fundus reflectance maps (four patients) and by means of heterochromatic flicker photometry (four patients). RESULTS: MOPD distribution showed an abnormal pattern for all patients with type 2 IMT. In correspondence to the late-phase hyperfluorescent areas shown by fluorescein angiography, MPOD was reduced in the macular area, while there was preserved MPOD at 5° to 7° eccentricity. CONCLUSIONS: The central depletion of macular pigment represents a novel phenotypic characteristic of type 2 IMT. Recording of macular pigment distribution may prove useful in the diagnosis of type 2 IMT and implicates an impaired trafficking or storage of lutein and zeaxanthin in the disease process.

Original languageEnglish (US)
Pages (from-to)808-816
Number of pages9
Issue number6
StatePublished - Jun 2008


  • Confocal scanning laser ophthalmoscope
  • Heterochromatic flicker photometry
  • Idiopathic juxtafoveolar telangiectasia
  • Idiopathic macular telangiectasia
  • Idiopathic parafoveolar telangiectasia
  • Macular pigment
  • Retinal telangiectasia

ASJC Scopus subject areas

  • Ophthalmology


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