TY - JOUR
T1 - Abnormal macular pigment distribution in type 2 idiopathic macular telangiectasia
AU - Helb, Hans Martin
AU - Charbel Issa, Peter
AU - Van Der Veen, Rob L.P.
AU - Berendschot, Tos T.J.M.
AU - Scholl, Hendrik P.N.
AU - Holz, Frank G.
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/6
Y1 - 2008/6
N2 - PURPOSE: To determine the distribution of macular pigment in type 2 idiopathic macular telangiectasia (IMT). METHODS: Twenty-two eyes of 12 patients with type 2 IMT were examined by means of best-corrected visual acuity testing, fundus biomicroscopy, fundus photography, fluorescein angiography, and optical coherence tomography. Macular pigment optical density (MPOD) was assessed using a modified confocal scanning laser ophthalmoscope whereby MPOD was calculated from fundus autofluorescence images acquired at two different excitation wavelengths (488 and 514 nm). The results were verified with a method that provides density maps after digital subtraction of log fundus reflectance maps (four patients) and by means of heterochromatic flicker photometry (four patients). RESULTS: MOPD distribution showed an abnormal pattern for all patients with type 2 IMT. In correspondence to the late-phase hyperfluorescent areas shown by fluorescein angiography, MPOD was reduced in the macular area, while there was preserved MPOD at 5° to 7° eccentricity. CONCLUSIONS: The central depletion of macular pigment represents a novel phenotypic characteristic of type 2 IMT. Recording of macular pigment distribution may prove useful in the diagnosis of type 2 IMT and implicates an impaired trafficking or storage of lutein and zeaxanthin in the disease process.
AB - PURPOSE: To determine the distribution of macular pigment in type 2 idiopathic macular telangiectasia (IMT). METHODS: Twenty-two eyes of 12 patients with type 2 IMT were examined by means of best-corrected visual acuity testing, fundus biomicroscopy, fundus photography, fluorescein angiography, and optical coherence tomography. Macular pigment optical density (MPOD) was assessed using a modified confocal scanning laser ophthalmoscope whereby MPOD was calculated from fundus autofluorescence images acquired at two different excitation wavelengths (488 and 514 nm). The results were verified with a method that provides density maps after digital subtraction of log fundus reflectance maps (four patients) and by means of heterochromatic flicker photometry (four patients). RESULTS: MOPD distribution showed an abnormal pattern for all patients with type 2 IMT. In correspondence to the late-phase hyperfluorescent areas shown by fluorescein angiography, MPOD was reduced in the macular area, while there was preserved MPOD at 5° to 7° eccentricity. CONCLUSIONS: The central depletion of macular pigment represents a novel phenotypic characteristic of type 2 IMT. Recording of macular pigment distribution may prove useful in the diagnosis of type 2 IMT and implicates an impaired trafficking or storage of lutein and zeaxanthin in the disease process.
KW - Confocal scanning laser ophthalmoscope
KW - Heterochromatic flicker photometry
KW - Idiopathic juxtafoveolar telangiectasia
KW - Idiopathic macular telangiectasia
KW - Idiopathic parafoveolar telangiectasia
KW - Macular pigment
KW - Retinal telangiectasia
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U2 - 10.1097/IAE.0b013e31816d81aa
DO - 10.1097/IAE.0b013e31816d81aa
M3 - Article
C2 - 18536596
AN - SCOPUS:47749091309
SN - 0275-004X
VL - 28
SP - 808
EP - 816
JO - Retina
JF - Retina
IS - 6
ER -