Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients

Michal Assaf, Kanchana Jagannathan, Vince D. Calhoun, Laura Miller, Michael C. Stevens, Robert Sahl, Jacqueline G. O'Boyle, Robert T. Schultz, Godfrey D. Pearlson

    Research output: Contribution to journalArticle


    Autism spectrum disorders (ASDs) are characterized by deficits in social and communication processes. Recent data suggest that altered functional connectivity (FC), i.e. synchronous brain activity, might contribute to these deficits. Of specific interest is the FC integrity of the default mode network (DMN), a network active during passive resting states and cognitive processes related to social deficits seen in ASD, e.g. Theory of Mind. We investigated the role of altered FC of default mode sub-networks (DM-SNs) in 16 patients with high-functioning ASD compared to 16 matched healthy controls of short resting fMRI scans using independent component analysis (ICA). ICA is a multivariate data-driven approach that identifies temporally coherent networks, providing a natural measure of FC. Results show that compared to controls, patients showed decreased FC between the precuneus and medial prefrontal cortex/anterior cingulate cortex, DMN core areas, and other DM-SNs areas. FC magnitude in these regions inversely correlated with the severity of patients' social and communication deficits as measured by the Autism Diagnostic Observational Schedule and the Social Responsiveness Scale. Importantly, supplemental analyses suggest that these results were independent of treatment status. These results support the hypothesis that DM-SNs under-connectivity contributes to the core deficits seen in ASD. Moreover, these data provide further support for the use of data-driven analysis with resting-state data for illuminating neural systems that differ between groups. This approach seems especially well suited for populations where compliance with and performance of active tasks might be a challenge, as it requires minimal cooperation.

    Original languageEnglish (US)
    Pages (from-to)247-256
    Number of pages10
    Issue number1
    StatePublished - Oct 1 2010



    • Default mode network
    • Functional MRI
    • High-functioning autism
    • Independent component analysis
    • Resting state

    ASJC Scopus subject areas

    • Neurology
    • Cognitive Neuroscience

    Cite this

    Assaf, M., Jagannathan, K., Calhoun, V. D., Miller, L., Stevens, M. C., Sahl, R., O'Boyle, J. G., Schultz, R. T., & Pearlson, G. D. (2010). Abnormal functional connectivity of default mode sub-networks in autism spectrum disorder patients. NeuroImage, 53(1), 247-256. https://doi.org/10.1016/j.neuroimage.2010.05.067