Abnormal expression of cell recognition molecules in schizophrenia

Marquis P. Vawter, H. Eleanor Cannon-Spoor, John J. Hemperly, Thomas M. Hyde, Dale M. Vanderputten, Joel E. Kleinman, William J. Freed

Research output: Contribution to journalArticlepeer-review

Abstract

Schizophrenia is a neuropsychiatric disorder of unknown etiology associated with subtle changes in brain morphology. The cell recognition molecules (CRMs) neural cell adhesion molecule (N-CAM) and L1 are involved in morphoregulatory events and numerous neurodevelopmental processes. We found a selective increase of 105- to 115-kDa N-CAM in the hippocampus and prefrontal cortex of patients with schizophrenia while other N-CAM isoforms and L1 proteins were not altered. There was also evidence for an abnormality in CRM expression in schizophrenic patients: concentrations of 200-kDa L1 were strongly correlated with expression of N-CAM isoforms and cleaved L1 proteins in controls, whereas these correlations were absent in patients with schizophrenia. The increase of the 105- to 115-kDa N-CAM isoform in the brains of patients with schizophrenia confirms previous cerebrospinal fluid findings. Increased N-CAM in schizophrenia may result from structural brain abnormalities, from glial processing of N-CAM, or from an aberration in the regulation of N-CAM expression.

Original languageEnglish (US)
Pages (from-to)424-432
Number of pages9
JournalExperimental Neurology
Volume149
Issue number2
DOIs
StatePublished - Feb 1998
Externally publishedYes

Keywords

  • Bipolar disorder
  • Hippocampus
  • L1, cell recognition molecules
  • Neural cell adhesion molecule
  • Prefrontal cortex
  • Schizophrenia
  • Suicide

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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