Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome

Research output: Contribution to journalArticle

Abstract

The dopamine hypothesis for Tourette's syndrome proposes that the disorder is pathologically related either to an excessive amount of dopamine or to supersensitive receptors. To evaluate these proposals, pre- and postsynaptic markers of dopamine metabolism were measured in postmortem striatum from three adults with the diagnosis of Tourette's syndrome. Neuronal dopamine uptake carrier sites ([3H]mazindol binding) were significantly increased in number over control values by 37% in the caudate and by 50% in the putamen. High-pressure liquid Chromatographic assays of dopamine and its primary metabolites, homovanillic acid and 3,4-dihydroxyphenylacetic acid, showed normal findings. D1 and D2 subtypes of dopaminergic receptors ([3H]SCH 23390 and [3H]spiperone binding, respectively) showed only slight alterations, presumably due to treatment with neoroleptics. The concentration of adenosine 3′,5′-monophosphate (cyclic AMP) in putamen was reduced by 23%. Our data support earlier proposals of a dopaminergic abnormality in TS, but suggest that the mechanism involves a significant alteration of uptake sites. We speculate that increases in carrier site binding indicate an enhanced dopamine innervation within the striatum.

Original languageEnglish (US)
Pages (from-to)558-562
Number of pages5
JournalAnnals of Neurology
Volume30
Issue number4
StatePublished - Oct 1991

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Tourette Syndrome
Dopamine
Putamen
Mazindol
Spiperone
3,4-Dihydroxyphenylacetic Acid
Homovanillic Acid
Dopamine Plasma Membrane Transport Proteins
Cyclic AMP
Adenosine
Binding Sites
Pressure

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Abnormal dopamine uptake sites in postmortem striatum from patients with Tourette's syndrome. / Singer, Harvey; Hahn, In Hei; Moran, Timothy H.

In: Annals of Neurology, Vol. 30, No. 4, 10.1991, p. 558-562.

Research output: Contribution to journalArticle

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