Abnormal development of the lesser wing of the sphenoid with microphthalmos and microcephaly

C. Jacquemin, P. Mullaney, T. M. Bosley

Research output: Contribution to journalArticle

Abstract

We report two patients with abnormal development of the lesser wing of the sphenoid bone, globe, optic nerve and cerebral hemisphere without stigmata of neurofibromatosis type 1. The lesser wing of the sphenoid bone was abnormally formed and was not ossified ipsilateral to the dysmorphic eye and underdeveloped cerebral hemisphere. Maldevelopment of the sphenoid wing may interfere with the normal closure of the optic vesicle and normal growth of encephalic structures, possibly by disturbing developmental tissue interactions. These patients may exhibit a type of restricted primary sphenoid dysplasia, while the sphenoid dysplasia of neurofibromatosis type 1 may be secondary to orbital or ocular neurofibromas and other factors associated with that disease.

Original languageEnglish (US)
Pages (from-to)178-182
Number of pages5
JournalNeuroradiology
Volume43
Issue number2
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Keywords

  • Microphthalmos
  • Neurofibromatosis type 1
  • Sphenoid bone, developmental anomaly

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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