Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder

Attenuated by medication

Danella M. Hafeman, Genna Bebko, Michele A. Bertocci, Jay C. Fournier, Lisa Bonar, Susan B. Perlman, Michael Travis, Mary Kay Gill, Vaibhav A. Diwadkar, Jeffrey L. Sunshine, Scott K. Holland, Robert A. Kowatch, Boris Birmaher, David Axelson, Sarah M. Horwitz, L. Eugene Arnold, Mary A. Fristad, Thomas W. Frazier, Eric A. Youngstrom, Robert L Findling & 2 others Wayne Drevets, Mary L. Phillips

Research output: Contribution to journalArticle

Abstract

Previous neuroimaging studies of youth with bipolar disorder (BD) have identified abnormalities in emotion regulation circuitry. Using data from the Longitudinal Assessment of Manic Symptoms Cohort (a clinical sample recruited for behavioral and emotional dysregulation), we examined the impact of BD and medication on activation in these regions. Functional neuroimaging data were obtained from 15 youth with BD who currently were unmedicated with a mood stabilizer or antipsychotic (U-BD), 19 youth with medicated BD (M-BD), a non-bipolar clinical sample with high rates of disruptive behavioral disorders (non-BD, n=59), and 29 healthy controls (HC) while they were shown task-irrelevant morphing emotional faces and shapes. Whole brain analysis was used to identify clusters that showed differential activation to emotion vs. shapes across group. To assess pair-wise comparisons and potential confounders, mean activation data were extracted only from clusters within regions previously implicated in emotion regulation (including amygdala and ventral prefrontal regions). A cluster in the right inferior frontal gyrus (IFG) showed group differences to emotion vs. shapes (159 voxels, corrected p

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalJournal of Psychiatric Research
Volume58
DOIs
StatePublished - Nov 1 2014

Fingerprint

Prefrontal Cortex
Bipolar Disorder
Emotions
Functional Neuroimaging
Symptom Assessment
Amygdala
Neuroimaging
Antipsychotic Agents
Emotion
Medication
Inferior Frontal Gyrus
Brain
Activation
Emotion Regulation

Keywords

  • Bipolar disorder
  • Emotion regulation
  • Functional MRI (fMRI)
  • Neuroimaging
  • Psychopharmacology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Arts and Humanities (miscellaneous)

Cite this

Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder : Attenuated by medication. / Hafeman, Danella M.; Bebko, Genna; Bertocci, Michele A.; Fournier, Jay C.; Bonar, Lisa; Perlman, Susan B.; Travis, Michael; Gill, Mary Kay; Diwadkar, Vaibhav A.; Sunshine, Jeffrey L.; Holland, Scott K.; Kowatch, Robert A.; Birmaher, Boris; Axelson, David; Horwitz, Sarah M.; Arnold, L. Eugene; Fristad, Mary A.; Frazier, Thomas W.; Youngstrom, Eric A.; Findling, Robert L; Drevets, Wayne; Phillips, Mary L.

In: Journal of Psychiatric Research, Vol. 58, 01.11.2014, p. 129-136.

Research output: Contribution to journalArticle

Hafeman, DM, Bebko, G, Bertocci, MA, Fournier, JC, Bonar, L, Perlman, SB, Travis, M, Gill, MK, Diwadkar, VA, Sunshine, JL, Holland, SK, Kowatch, RA, Birmaher, B, Axelson, D, Horwitz, SM, Arnold, LE, Fristad, MA, Frazier, TW, Youngstrom, EA, Findling, RL, Drevets, W & Phillips, ML 2014, 'Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder: Attenuated by medication', Journal of Psychiatric Research, vol. 58, pp. 129-136. https://doi.org/10.1016/j.jpsychires.2014.07.023
Hafeman, Danella M. ; Bebko, Genna ; Bertocci, Michele A. ; Fournier, Jay C. ; Bonar, Lisa ; Perlman, Susan B. ; Travis, Michael ; Gill, Mary Kay ; Diwadkar, Vaibhav A. ; Sunshine, Jeffrey L. ; Holland, Scott K. ; Kowatch, Robert A. ; Birmaher, Boris ; Axelson, David ; Horwitz, Sarah M. ; Arnold, L. Eugene ; Fristad, Mary A. ; Frazier, Thomas W. ; Youngstrom, Eric A. ; Findling, Robert L ; Drevets, Wayne ; Phillips, Mary L. / Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder : Attenuated by medication. In: Journal of Psychiatric Research. 2014 ; Vol. 58. pp. 129-136.
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