Abstract
Previous neuroimaging studies of youth with bipolar disorder (BD) have identified abnormalities in emotion regulation circuitry. Using data from the Longitudinal Assessment of Manic Symptoms Cohort (a clinical sample recruited for behavioral and emotional dysregulation), we examined the impact of BD and medication on activation in these regions. Functional neuroimaging data were obtained from 15 youth with BD who currently were unmedicated with a mood stabilizer or antipsychotic (U-BD), 19 youth with medicated BD (M-BD), a non-bipolar clinical sample with high rates of disruptive behavioral disorders (non-BD, n=59), and 29 healthy controls (HC) while they were shown task-irrelevant morphing emotional faces and shapes. Whole brain analysis was used to identify clusters that showed differential activation to emotion vs. shapes across group. To assess pair-wise comparisons and potential confounders, mean activation data were extracted only from clusters within regions previously implicated in emotion regulation (including amygdala and ventral prefrontal regions). A cluster in the right inferior frontal gyrus (IFG) showed group differences to emotion vs. shapes (159 voxels, corrected p
| Original language | English (US) |
|---|---|
| Pages (from-to) | 129-136 |
| Number of pages | 8 |
| Journal | Journal of Psychiatric Research |
| Volume | 58 |
| DOIs | |
| State | Published - Nov 1 2014 |
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Keywords
- Bipolar disorder
- Emotion regulation
- Functional MRI (fMRI)
- Neuroimaging
- Psychopharmacology
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
- Arts and Humanities (miscellaneous)
Cite this
Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder : Attenuated by medication. / Hafeman, Danella M.; Bebko, Genna; Bertocci, Michele A.; Fournier, Jay C.; Bonar, Lisa; Perlman, Susan B.; Travis, Michael; Gill, Mary Kay; Diwadkar, Vaibhav A.; Sunshine, Jeffrey L.; Holland, Scott K.; Kowatch, Robert A.; Birmaher, Boris; Axelson, David; Horwitz, Sarah M.; Arnold, L. Eugene; Fristad, Mary A.; Frazier, Thomas W.; Youngstrom, Eric A.; Findling, Robert L; Drevets, Wayne; Phillips, Mary L.
In: Journal of Psychiatric Research, Vol. 58, 01.11.2014, p. 129-136.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder
T2 - Attenuated by medication
AU - Hafeman, Danella M.
AU - Bebko, Genna
AU - Bertocci, Michele A.
AU - Fournier, Jay C.
AU - Bonar, Lisa
AU - Perlman, Susan B.
AU - Travis, Michael
AU - Gill, Mary Kay
AU - Diwadkar, Vaibhav A.
AU - Sunshine, Jeffrey L.
AU - Holland, Scott K.
AU - Kowatch, Robert A.
AU - Birmaher, Boris
AU - Axelson, David
AU - Horwitz, Sarah M.
AU - Arnold, L. Eugene
AU - Fristad, Mary A.
AU - Frazier, Thomas W.
AU - Youngstrom, Eric A.
AU - Findling, Robert L
AU - Drevets, Wayne
AU - Phillips, Mary L.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Previous neuroimaging studies of youth with bipolar disorder (BD) have identified abnormalities in emotion regulation circuitry. Using data from the Longitudinal Assessment of Manic Symptoms Cohort (a clinical sample recruited for behavioral and emotional dysregulation), we examined the impact of BD and medication on activation in these regions. Functional neuroimaging data were obtained from 15 youth with BD who currently were unmedicated with a mood stabilizer or antipsychotic (U-BD), 19 youth with medicated BD (M-BD), a non-bipolar clinical sample with high rates of disruptive behavioral disorders (non-BD, n=59), and 29 healthy controls (HC) while they were shown task-irrelevant morphing emotional faces and shapes. Whole brain analysis was used to identify clusters that showed differential activation to emotion vs. shapes across group. To assess pair-wise comparisons and potential confounders, mean activation data were extracted only from clusters within regions previously implicated in emotion regulation (including amygdala and ventral prefrontal regions). A cluster in the right inferior frontal gyrus (IFG) showed group differences to emotion vs. shapes (159 voxels, corrected p
AB - Previous neuroimaging studies of youth with bipolar disorder (BD) have identified abnormalities in emotion regulation circuitry. Using data from the Longitudinal Assessment of Manic Symptoms Cohort (a clinical sample recruited for behavioral and emotional dysregulation), we examined the impact of BD and medication on activation in these regions. Functional neuroimaging data were obtained from 15 youth with BD who currently were unmedicated with a mood stabilizer or antipsychotic (U-BD), 19 youth with medicated BD (M-BD), a non-bipolar clinical sample with high rates of disruptive behavioral disorders (non-BD, n=59), and 29 healthy controls (HC) while they were shown task-irrelevant morphing emotional faces and shapes. Whole brain analysis was used to identify clusters that showed differential activation to emotion vs. shapes across group. To assess pair-wise comparisons and potential confounders, mean activation data were extracted only from clusters within regions previously implicated in emotion regulation (including amygdala and ventral prefrontal regions). A cluster in the right inferior frontal gyrus (IFG) showed group differences to emotion vs. shapes (159 voxels, corrected p
KW - Bipolar disorder
KW - Emotion regulation
KW - Functional MRI (fMRI)
KW - Neuroimaging
KW - Psychopharmacology
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UR - http://www.scopus.com/inward/citedby.url?scp=84912534179&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2014.07.023
DO - 10.1016/j.jpsychires.2014.07.023
M3 - Article
VL - 58
SP - 129
EP - 136
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
SN - 0022-3956
ER -