Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia

Esther Oh, Kaj Blennow, George Bigelow, Sharon K. Inouye, Edward R. Marcantonio, Karin Jane Neufeld, Paul B Rosenberg, Juan C Troncoso, Nae Yuh Wang, Henrik Zetterberg, Frederick Sieber, Constantine G Lyketsos

Research output: Contribution to journalArticle

Abstract

Background There is strong association of Alzheimer's disease (AD) pathology with gait disorder and falls in older adults without dementia. The goal of the study was to examine the prevalence and severity of AD pathology in older adults without dementia who fall and sustain hip fracture. Methods Cerebrospinal fluid (CSF) was obtained from 168 hip fracture patients. CSF Aβ42/40 ratio, p-tau, and t-tau measures were dichotomized into normal vs. abnormal, and categorized according to the A/T/N classification. Results Among the hip fracture patients, 88.6% of the cognitively normal (Clinical Dementia Rating- CDR 0; n = 70) and 98.8% with mild cognitive impairment (CDR 0.5; n = 81) fell in the abnormal biomarker categories by the A/T/N classification. Conclusions A large proportion of older hip fracture patients have CSF evidence of AD pathology. Preoperative determination of AD biomarkers may play a crucial role in identifying persons without dementia who have underlying AD pathology in perioperative settings.

Original languageEnglish (US)
Article numbere0204695
JournalPLoS One
Volume13
Issue number9
DOIs
StatePublished - Sep 1 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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