Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility–sensitized MRI

P. Hedera, S. Lai, E. M. Haacke, A. J. Lerner, A. L. Hopkins, J. S. Lewin, R. P. Friedland

Research output: Contribution to journalArticle

Abstract

We studied activation of the human visual cortex (VC) using susceptibility-sensitized MRI at 1.5 Tesla. Three albinos and six healthy controls underwent a series of monocular and binocular photic flash stimulation. Monocular stimulation in albinos caused predominant contralateral activation with a small, well-delineated area in the anterior part of the VC in the ipsilateral hemisphere. This finding was consistent with a chiasmal crossing anomaly in albinism. All controls had symmetric patterns of activation during monocular stimulation. Functional MEI represents a promising method for evaluation of the visual pathways in humans.

Original languageEnglish (US)
Pages (from-to)1921-1926
Number of pages6
JournalNeurology
Volume44
Issue number10
DOIs
StatePublished - Oct 1994

ASJC Scopus subject areas

  • Clinical Neurology

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    Hedera, P., Lai, S., Haacke, E. M., Lerner, A. J., Hopkins, A. L., Lewin, J. S., & Friedland, R. P. (1994). Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility–sensitized MRI. Neurology, 44(10), 1921-1926. https://doi.org/10.1212/wnl.44.10.1921