Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility–sensitized MRI

P. Hedera; S. Lai; E. M. Haacke; A. J. Lerner; A. L. Hopkins; J. S. Lewin; R. P. Friedland

doi:10.1212/wnl.44.10.1921

Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility–sensitized MRI

P. Hedera, S. Lai, E. M. Haacke, A. J. Lerner, A. L. Hopkins, J. S. Lewin, R. P. Friedland

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We studied activation of the human visual cortex (VC) using susceptibility-sensitized MRI at 1.5 Tesla. Three albinos and six healthy controls underwent a series of monocular and binocular photic flash stimulation. Monocular stimulation in albinos caused predominant contralateral activation with a small, well-delineated area in the anterior part of the VC in the ipsilateral hemisphere. This finding was consistent with a chiasmal crossing anomaly in albinism. All controls had symmetric patterns of activation during monocular stimulation. Functional MEI represents a promising method for evaluation of the visual pathways in humans.

Original language	English (US)
Pages (from-to)	1921-1926
Number of pages	6
Journal	Neurology
Volume	44
Issue number	10
DOIs	https://doi.org/10.1212/wnl.44.10.1921
State	Published - Oct 1994
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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title = "Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility–sensitized MRI",

abstract = "We studied activation of the human visual cortex (VC) using susceptibility-sensitized MRI at 1.5 Tesla. Three albinos and six healthy controls underwent a series of monocular and binocular photic flash stimulation. Monocular stimulation in albinos caused predominant contralateral activation with a small, well-delineated area in the anterior part of the VC in the ipsilateral hemisphere. This finding was consistent with a chiasmal crossing anomaly in albinism. All controls had symmetric patterns of activation during monocular stimulation. Functional MEI represents a promising method for evaluation of the visual pathways in humans.",

author = "P. Hedera and S. Lai and Haacke, {E. M.} and Lerner, {A. J.} and Hopkins, {A. L.} and Lewin, {J. S.} and Friedland, {R. P.}",

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T1 - Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility–sensitized MRI

AU - Hedera, P.

AU - Lai, S.

AU - Haacke, E. M.

AU - Lerner, A. J.

AU - Hopkins, A. L.

AU - Lewin, J. S.

AU - Friedland, R. P.

PY - 1994/10

Y1 - 1994/10

N2 - We studied activation of the human visual cortex (VC) using susceptibility-sensitized MRI at 1.5 Tesla. Three albinos and six healthy controls underwent a series of monocular and binocular photic flash stimulation. Monocular stimulation in albinos caused predominant contralateral activation with a small, well-delineated area in the anterior part of the VC in the ipsilateral hemisphere. This finding was consistent with a chiasmal crossing anomaly in albinism. All controls had symmetric patterns of activation during monocular stimulation. Functional MEI represents a promising method for evaluation of the visual pathways in humans.

AB - We studied activation of the human visual cortex (VC) using susceptibility-sensitized MRI at 1.5 Tesla. Three albinos and six healthy controls underwent a series of monocular and binocular photic flash stimulation. Monocular stimulation in albinos caused predominant contralateral activation with a small, well-delineated area in the anterior part of the VC in the ipsilateral hemisphere. This finding was consistent with a chiasmal crossing anomaly in albinism. All controls had symmetric patterns of activation during monocular stimulation. Functional MEI represents a promising method for evaluation of the visual pathways in humans.

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Abnormal connectivity of the visual pathways in human albinos demonstrated by susceptibility–sensitized MRI

Abstract

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