Abnormal coagulation profile in brain tumor patients during surgery

Thomas J. Iberti, Myron Miller, Amy Abalos, Ellen P. Fischer, Kalmon D. Post, Ernest Benjamin, John M. Oropello, Michelle Wiltshire-Clement, Jacob H. Rand

Research output: Contribution to journalArticle

Abstract

NEUROSURGICAL PATIENTS ARE at high risk for the development of thrombosis and thromboembolism. We compared the perioperative clotting factor and coagulation parameters of 20 patients undergoing elective craniotomy for brain tumors to those of 20 patients undergoing elective abdominal surgery. We also measured the levels of plasma arginine vasopressin to determine if changes in this hormone might be associated with changes in clotting factors, activated partial thromboplastin times, or bleeding times. The results demonstrated a significant reduction in partial thromboplastin times and bleeding times in the neurosurgery group, which began at the initiation of surgery and lasted to the end of the study (12 h postoperatively). Elevations in factor assays and plasma arginine vasopressin occurred in both groups during surgery, but there were no differences between the neurosurgical and abdominal surgical patients, except with Factor IX levels, which were elevated only in the neurosurgical patients. Serum osmolality and hemoglobin levels were significantly higher in the neurosurgical cohort. These results suggest that there are hemostatic differences between neurosurgical patients with brain tumors and abdominal surgery patients that cannot be explained solely by elevations in plasma arginine vasopressin or the clotting factors measured; these differences may be the consequence of perioperative variables such as dehydration and hyperosmolality.

Original languageEnglish (US)
Pages (from-to)389-395
Number of pages7
JournalNeurosurgery
Volume34
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Brain Neoplasms
Blood Coagulation Factors
Arginine Vasopressin
Bleeding Time
Partial Thromboplastin Time
Factor IX
Craniotomy
Thromboembolism
Neurosurgery
Hemostatics
Dehydration
Osmolar Concentration
Hemoglobins
Thrombosis
Hormones
Serum

Keywords

  • Arginine vasopressin
  • Bleeding time
  • Brain tumor
  • Hemostasis
  • Neurosurgical
  • Thrombosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Iberti, T. J., Miller, M., Abalos, A., Fischer, E. P., Post, K. D., Benjamin, E., ... Rand, J. H. (1994). Abnormal coagulation profile in brain tumor patients during surgery. Neurosurgery, 34(3), 389-395.

Abnormal coagulation profile in brain tumor patients during surgery. / Iberti, Thomas J.; Miller, Myron; Abalos, Amy; Fischer, Ellen P.; Post, Kalmon D.; Benjamin, Ernest; Oropello, John M.; Wiltshire-Clement, Michelle; Rand, Jacob H.

In: Neurosurgery, Vol. 34, No. 3, 1994, p. 389-395.

Research output: Contribution to journalArticle

Iberti, TJ, Miller, M, Abalos, A, Fischer, EP, Post, KD, Benjamin, E, Oropello, JM, Wiltshire-Clement, M & Rand, JH 1994, 'Abnormal coagulation profile in brain tumor patients during surgery', Neurosurgery, vol. 34, no. 3, pp. 389-395.
Iberti TJ, Miller M, Abalos A, Fischer EP, Post KD, Benjamin E et al. Abnormal coagulation profile in brain tumor patients during surgery. Neurosurgery. 1994;34(3):389-395.
Iberti, Thomas J. ; Miller, Myron ; Abalos, Amy ; Fischer, Ellen P. ; Post, Kalmon D. ; Benjamin, Ernest ; Oropello, John M. ; Wiltshire-Clement, Michelle ; Rand, Jacob H. / Abnormal coagulation profile in brain tumor patients during surgery. In: Neurosurgery. 1994 ; Vol. 34, No. 3. pp. 389-395.
@article{9ef9c7cabe624cf98245447296e6d33a,
title = "Abnormal coagulation profile in brain tumor patients during surgery",
abstract = "NEUROSURGICAL PATIENTS ARE at high risk for the development of thrombosis and thromboembolism. We compared the perioperative clotting factor and coagulation parameters of 20 patients undergoing elective craniotomy for brain tumors to those of 20 patients undergoing elective abdominal surgery. We also measured the levels of plasma arginine vasopressin to determine if changes in this hormone might be associated with changes in clotting factors, activated partial thromboplastin times, or bleeding times. The results demonstrated a significant reduction in partial thromboplastin times and bleeding times in the neurosurgery group, which began at the initiation of surgery and lasted to the end of the study (12 h postoperatively). Elevations in factor assays and plasma arginine vasopressin occurred in both groups during surgery, but there were no differences between the neurosurgical and abdominal surgical patients, except with Factor IX levels, which were elevated only in the neurosurgical patients. Serum osmolality and hemoglobin levels were significantly higher in the neurosurgical cohort. These results suggest that there are hemostatic differences between neurosurgical patients with brain tumors and abdominal surgery patients that cannot be explained solely by elevations in plasma arginine vasopressin or the clotting factors measured; these differences may be the consequence of perioperative variables such as dehydration and hyperosmolality.",
keywords = "Arginine vasopressin, Bleeding time, Brain tumor, Hemostasis, Neurosurgical, Thrombosis",
author = "Iberti, {Thomas J.} and Myron Miller and Amy Abalos and Fischer, {Ellen P.} and Post, {Kalmon D.} and Ernest Benjamin and Oropello, {John M.} and Michelle Wiltshire-Clement and Rand, {Jacob H.}",
year = "1994",
language = "English (US)",
volume = "34",
pages = "389--395",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Abnormal coagulation profile in brain tumor patients during surgery

AU - Iberti, Thomas J.

AU - Miller, Myron

AU - Abalos, Amy

AU - Fischer, Ellen P.

AU - Post, Kalmon D.

AU - Benjamin, Ernest

AU - Oropello, John M.

AU - Wiltshire-Clement, Michelle

AU - Rand, Jacob H.

PY - 1994

Y1 - 1994

N2 - NEUROSURGICAL PATIENTS ARE at high risk for the development of thrombosis and thromboembolism. We compared the perioperative clotting factor and coagulation parameters of 20 patients undergoing elective craniotomy for brain tumors to those of 20 patients undergoing elective abdominal surgery. We also measured the levels of plasma arginine vasopressin to determine if changes in this hormone might be associated with changes in clotting factors, activated partial thromboplastin times, or bleeding times. The results demonstrated a significant reduction in partial thromboplastin times and bleeding times in the neurosurgery group, which began at the initiation of surgery and lasted to the end of the study (12 h postoperatively). Elevations in factor assays and plasma arginine vasopressin occurred in both groups during surgery, but there were no differences between the neurosurgical and abdominal surgical patients, except with Factor IX levels, which were elevated only in the neurosurgical patients. Serum osmolality and hemoglobin levels were significantly higher in the neurosurgical cohort. These results suggest that there are hemostatic differences between neurosurgical patients with brain tumors and abdominal surgery patients that cannot be explained solely by elevations in plasma arginine vasopressin or the clotting factors measured; these differences may be the consequence of perioperative variables such as dehydration and hyperosmolality.

AB - NEUROSURGICAL PATIENTS ARE at high risk for the development of thrombosis and thromboembolism. We compared the perioperative clotting factor and coagulation parameters of 20 patients undergoing elective craniotomy for brain tumors to those of 20 patients undergoing elective abdominal surgery. We also measured the levels of plasma arginine vasopressin to determine if changes in this hormone might be associated with changes in clotting factors, activated partial thromboplastin times, or bleeding times. The results demonstrated a significant reduction in partial thromboplastin times and bleeding times in the neurosurgery group, which began at the initiation of surgery and lasted to the end of the study (12 h postoperatively). Elevations in factor assays and plasma arginine vasopressin occurred in both groups during surgery, but there were no differences between the neurosurgical and abdominal surgical patients, except with Factor IX levels, which were elevated only in the neurosurgical patients. Serum osmolality and hemoglobin levels were significantly higher in the neurosurgical cohort. These results suggest that there are hemostatic differences between neurosurgical patients with brain tumors and abdominal surgery patients that cannot be explained solely by elevations in plasma arginine vasopressin or the clotting factors measured; these differences may be the consequence of perioperative variables such as dehydration and hyperosmolality.

KW - Arginine vasopressin

KW - Bleeding time

KW - Brain tumor

KW - Hemostasis

KW - Neurosurgical

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=20244374398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20244374398&partnerID=8YFLogxK

M3 - Article

C2 - 8190212

AN - SCOPUS:20244374398

VL - 34

SP - 389

EP - 395

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 3

ER -