TY - JOUR
T1 - Abnormal brain structure implicated in patients with functional dyspepsia
AU - Liu, Peng
AU - Wang, Geliang
AU - Zeng, Fang
AU - Liu, Yanfei
AU - Fan, Yingying
AU - Wei, Ying
AU - Qin, Wei
AU - Calhoun, Vince D.
N1 - Funding Information:
Funding This study was supported by the National Natural Science Foundation of China under Grant Nos. 81,471,738, 81,303,060, 81,271,644, 81,471,811 and 61,401,346,National Basic Research Program of China under Grant Nos. 2014CB543203 and 2015CB856403, the Special Fund for the Authors Who win the 100 Top Doctoral Dissertations Award of China No. 2014084, the Education Ministry’s New Century Excellent Talents Supporting Plan, and NIH 1R01EB006841, R01EB005846 and P20GM103472.
Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Recent studies suggest dysfunctional brain-gut interactions are involved in the pathophysiology of functional dyspepsia (FD). However, limited studies have investigated brain structural abnormalities in FD patients. This study aimed to identify potential differences in both cortical thickness and subcortical volume in FD patients compared to healthy controls (HCs) and to explore relationships of structural abnormalities with clinical symptoms. Sixty-nine patients and forty-nine HCs underwent 3T structural magnetic resonance imaging scans. Cortical thickness and subcortical volume were compared between the groups across the cortical and subcortical regions, respectively. Regression analysis was then performed to examine relationships between the structure alternations and clinical symptoms in FD patients. Our results showed that FD patients had decreased cortical thickness compared to HCs in the distributed brain regions including the dorsolateral prefrontal cortex (dlPFC), ventrolateral prefrontal cortex (vlPFC), medial prefrontal cortex (mPFC), anterior/posterior cingulate cortex (ACC/PCC), insula, superior parietal cortex (SPC), supramarginal gyrus and lingual gyrus. Significantly negative correlations were observed between the Nepean Dyspepsia Index (NDI) and cortical thickness in the mPFC, second somatosensory cortex (SII), ACC and parahippocampus (paraHIPP). And significantly negative correlations were found between disease duration and the cortical thickness in the vlPFC, first somatosensory cortex (SI) and insula in FD patients. These findings suggest that FD patients have structural abnormalities in brain regions involved in sensory perception, sensorimotor integration, pain modulation, affective and cognitive controls. The relationships between the brain structural changes and clinical symptoms indicate that the alternations may be a consequence of living with FD.
AB - Recent studies suggest dysfunctional brain-gut interactions are involved in the pathophysiology of functional dyspepsia (FD). However, limited studies have investigated brain structural abnormalities in FD patients. This study aimed to identify potential differences in both cortical thickness and subcortical volume in FD patients compared to healthy controls (HCs) and to explore relationships of structural abnormalities with clinical symptoms. Sixty-nine patients and forty-nine HCs underwent 3T structural magnetic resonance imaging scans. Cortical thickness and subcortical volume were compared between the groups across the cortical and subcortical regions, respectively. Regression analysis was then performed to examine relationships between the structure alternations and clinical symptoms in FD patients. Our results showed that FD patients had decreased cortical thickness compared to HCs in the distributed brain regions including the dorsolateral prefrontal cortex (dlPFC), ventrolateral prefrontal cortex (vlPFC), medial prefrontal cortex (mPFC), anterior/posterior cingulate cortex (ACC/PCC), insula, superior parietal cortex (SPC), supramarginal gyrus and lingual gyrus. Significantly negative correlations were observed between the Nepean Dyspepsia Index (NDI) and cortical thickness in the mPFC, second somatosensory cortex (SII), ACC and parahippocampus (paraHIPP). And significantly negative correlations were found between disease duration and the cortical thickness in the vlPFC, first somatosensory cortex (SI) and insula in FD patients. These findings suggest that FD patients have structural abnormalities in brain regions involved in sensory perception, sensorimotor integration, pain modulation, affective and cognitive controls. The relationships between the brain structural changes and clinical symptoms indicate that the alternations may be a consequence of living with FD.
KW - Cortical thickness
KW - Functional dyspepsia
KW - MRI
KW - Subcortical volume
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U2 - 10.1007/s11682-017-9705-z
DO - 10.1007/s11682-017-9705-z
M3 - Article
C2 - 28353135
AN - SCOPUS:85016099701
SN - 1931-7557
VL - 12
SP - 459
EP - 466
JO - Brain Imaging and Behavior
JF - Brain Imaging and Behavior
IS - 2
ER -