Ability of Reduced Lung Function to Predict Development of Atrial Fibrillation in Persons Aged 45 to 84 Years (from the Multi-Ethnic Study of Atherosclerosis-Lung Study)

Harjit Chahal, Susan R. Heckbert, R. Graham Barr, David A. Bluemke, Aditya Jain, Mohammadali Habibi, Alvaro Alonso, Richard Kronmal, David R. Jacobs, Joao A.C. Lima, Karol E. Watson, Kiang Liu, Lewis J. Smith, Philip Greenland

Research output: Contribution to journalArticle

Abstract

Atrial fibrillation (AF) occurs frequently in patients with chronic obstructive pulmonary disease. Epidemiologic studies have found inconsistent associations between lung function and AF, and none have studied pulmonary emphysema, which overlaps only partially with chronic obstructive pulmonary disease in the general population. The aim of this study was to assess the relation among lung function measured by spirometry, the percentage of emphysema-like lung on computed tomography, and incident AF. The Multi-Ethnic Study of Atherosclerosis (MESA) is a multicenter cohort study following 6,814 subjects free of clinical cardiovascular disease, including AF, at baseline. Spirometry was performed in a subset of 3,965 participants. Percentage emphysema was defined on baseline computed tomographic scans as lung regions <950 Hounsfield units. Incident AF was identified from hospital discharge diagnosis and Medicare claims data. Cox proportional hazards models were used to assess independent associations of lung volumes and percentage emphysema with AF. A total of 3,811 participants with valid spirometric results were included in this study. The mean age was 64.5 ± 9.8 years, and 49.4% were men. AF developed in 149 subjects (3.8%) over a mean follow-up period of 4.1 years after spirometry. Lower levels of forced expiratory volume at 1 second and forced vital capacity were associated with a higher risk for AF (hazard ratios 1.21 and 1.19 per 500 ml, respectively, p <0.001) after adjustment for demographic and cardiovascular risk factors. Percentage emphysema was not significantly related to AF. In conclusion, in a multiethnic community-based sample of subjects free of cardiovascular disease at baseline, functional airflow limitation was related to a higher risk for AF.

Original languageEnglish (US)
Article number21056
Pages (from-to)1700-1704
Number of pages5
JournalAmerican Journal of Cardiology
Volume115
Issue number12
DOIs
StatePublished - Jun 15 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Ability of Reduced Lung Function to Predict Development of Atrial Fibrillation in Persons Aged 45 to 84 Years (from the Multi-Ethnic Study of Atherosclerosis-Lung Study)'. Together they form a unique fingerprint.

  • Cite this

    Chahal, H., Heckbert, S. R., Barr, R. G., Bluemke, D. A., Jain, A., Habibi, M., Alonso, A., Kronmal, R., Jacobs, D. R., Lima, J. A. C., Watson, K. E., Liu, K., Smith, L. J., & Greenland, P. (2015). Ability of Reduced Lung Function to Predict Development of Atrial Fibrillation in Persons Aged 45 to 84 Years (from the Multi-Ethnic Study of Atherosclerosis-Lung Study). American Journal of Cardiology, 115(12), 1700-1704. [21056]. https://doi.org/10.1016/j.amjcard.2015.03.018