Aberrant splicing but not mutations of TSG101 in human breast cancer

Maxwell P. Lee, Andrew P. Feinberg

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


The llp15 gene TSG1O1 was recently reported to undergo frequent large intragenic deletions in human breast cancer. Here we show that that is generally not the case, but the gene shows aberrant splicing, based on the following observations: identical products were observed in matching normal and fetal tissues; deleted eDNA sequence revealed canonical splicing donor and acceptor site sequences; and genomic Southern blots showed no intragenic deletions in all 72 tumors studied. Nevertheless, relaxation of RNA splicing fidelity may be an oncodevelopmental marker in cancer and may play a general role in other genes and tumors.

Original languageEnglish (US)
Pages (from-to)3131-3134
Number of pages4
JournalCancer Research
Issue number15
StatePublished - 1997

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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