TY - JOUR
T1 - Aberrant paralimbic gray matter in incarcerated male adolescents with psychopathic traits
AU - Ermer, Elsa
AU - Cope, Lora M.
AU - Nyalakanti, Prashanth K.
AU - Calhoun, Vince D.
AU - Kiehl, Kent A.
N1 - Funding Information:
Disclosure: Dr. Calhoun has received research support from the National Institutes of Health (NIH), NIMH, the National Institute of Drug Abuse (NIDA), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Center for Research Resources, the National Science Foundation, the Defense Advanced Research Projects Agency, and the Department of Energy. He has served as a legal consultant, performed grant reviews for NIH, guest-edited journal sections, given academic lectures in various scientific venues, and generated books or book chapters for publishers of various texts. Dr. Kiehl has received grant support from NIH, NIMH, NIDA, NIBIB, NIAAA, and the John D. and Catherine T. MacArthur Foundation. He has performed grant reviews for NIH and other agencies, given academic lectures in various scientific venues and universities, and served as a consultant on judicial education for the states of Arizona, California, Illinois, Missouri, New Hampshire, and Nevada. Dr. Ermer, Ms. Cope, and Mr. Nyalakanti report no biomedical financial interests or potential conflicts of interest.
Funding Information:
This study was funded by the National Institute of Mental Health (NIMH) grant MH071896 (K.A.K., PI) and by NIMH National Research Service Award F32 MH086247 (E.E.).
PY - 2013/1
Y1 - 2013/1
N2 - Objective: To investigate the relationship between brain structure and psychopathic traits in maximum-security incarcerated male adolescents, and to examine whether the associations between brain volumes in paralimbic and limbic regions and psychopathic traits observed in incarcerated adult men extend to an independent sample of incarcerated male adolescents. Method: A structural magnetic resonance imaging (MRI) study of regional gray matter volumes by using voxel-based morphometry in maximum-security incarcerated male adolescents (N = 218) assessed for psychopathic traits using the Hare Psychopathy Checklist-Youth Version (PCL-YV). All analyses controlled for effects of age, substance use, and brain size. Results: Consistent with hypotheses and the adult literature, psychopathic traits were associated with decreased regional gray matter volumes in diffuse paralimbic regions, including orbitofrontal cortex, bilateral temporal poles, and posterior cingulate cortex. Conclusions: These results strengthen the interpretation that paralimbic regions are central for understanding neural dysfunction associated with psychopathic traits and that psychopathy is best conceptualized as a neurodevelopmental disorder.
AB - Objective: To investigate the relationship between brain structure and psychopathic traits in maximum-security incarcerated male adolescents, and to examine whether the associations between brain volumes in paralimbic and limbic regions and psychopathic traits observed in incarcerated adult men extend to an independent sample of incarcerated male adolescents. Method: A structural magnetic resonance imaging (MRI) study of regional gray matter volumes by using voxel-based morphometry in maximum-security incarcerated male adolescents (N = 218) assessed for psychopathic traits using the Hare Psychopathy Checklist-Youth Version (PCL-YV). All analyses controlled for effects of age, substance use, and brain size. Results: Consistent with hypotheses and the adult literature, psychopathic traits were associated with decreased regional gray matter volumes in diffuse paralimbic regions, including orbitofrontal cortex, bilateral temporal poles, and posterior cingulate cortex. Conclusions: These results strengthen the interpretation that paralimbic regions are central for understanding neural dysfunction associated with psychopathic traits and that psychopathy is best conceptualized as a neurodevelopmental disorder.
KW - antisocial
KW - juvenile delinquency
KW - paralimbic dysfunction
KW - psychopathy
KW - voxel-based morphometry
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U2 - 10.1016/j.jaac.2012.10.013
DO - 10.1016/j.jaac.2012.10.013
M3 - Article
C2 - 23265637
AN - SCOPUS:84871828683
SN - 0890-8567
VL - 52
SP - 94-103.e3
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 1
ER -