Aberrant methylation of the Ras-related Associated with Diabetes gene in human primary esophageal cancer

Zhe Jin, Xianling Feng, Qianhe Jian, Yulan Cheng, Yan Gao, Xiaojing Zhang, Liang Wang, Yuan Zhang, Weiling Huang, Xinmin Fan, Si Chen, Huimin Yu, Zhenfu Zhao, Ming Dong, Jie Liu, Yuriko Mori, Stephen Meltzer

Research output: Contribution to journalArticle

Abstract

Background/Aim: Ras-related associated with diabetes (RRAD), a member of the Ras-related GTPase superfamily, is frequently methylated in several human cancers, though its methylation profile remains unclear in esophageal cancer. Materials and Methods: We examined RRAD promoter hypermethylation using real-time quantitative methylation-specific PCR in 229 primary human esophageal tissues of contrasting histological types. Results: RRAD hypermethylation showed highly discriminative receiver-operator characteristic curve profiles, clearly distinguishing esophageal squamous cell carcinoma (ESCC) from esophageal adenocarcinoma (EAC) or normal esophagus (NE) (p

Original languageEnglish (US)
Pages (from-to)5199-5204
Number of pages6
JournalAnticancer Research
Volume33
Issue number11
StatePublished - Nov 2013

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Esophageal Neoplasms
Methylation
Monomeric GTP-Binding Proteins
Esophagus
Genes
Adenocarcinoma
Polymerase Chain Reaction
Neoplasms
Esophageal Squamous Cell Carcinoma

Keywords

  • EAC
  • ESCC
  • Hypermethylation
  • RRAD

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Aberrant methylation of the Ras-related Associated with Diabetes gene in human primary esophageal cancer. / Jin, Zhe; Feng, Xianling; Jian, Qianhe; Cheng, Yulan; Gao, Yan; Zhang, Xiaojing; Wang, Liang; Zhang, Yuan; Huang, Weiling; Fan, Xinmin; Chen, Si; Yu, Huimin; Zhao, Zhenfu; Dong, Ming; Liu, Jie; Mori, Yuriko; Meltzer, Stephen.

In: Anticancer Research, Vol. 33, No. 11, 11.2013, p. 5199-5204.

Research output: Contribution to journalArticle

Jin, Z, Feng, X, Jian, Q, Cheng, Y, Gao, Y, Zhang, X, Wang, L, Zhang, Y, Huang, W, Fan, X, Chen, S, Yu, H, Zhao, Z, Dong, M, Liu, J, Mori, Y & Meltzer, S 2013, 'Aberrant methylation of the Ras-related Associated with Diabetes gene in human primary esophageal cancer', Anticancer Research, vol. 33, no. 11, pp. 5199-5204.
Jin Z, Feng X, Jian Q, Cheng Y, Gao Y, Zhang X et al. Aberrant methylation of the Ras-related Associated with Diabetes gene in human primary esophageal cancer. Anticancer Research. 2013 Nov;33(11):5199-5204.
Jin, Zhe ; Feng, Xianling ; Jian, Qianhe ; Cheng, Yulan ; Gao, Yan ; Zhang, Xiaojing ; Wang, Liang ; Zhang, Yuan ; Huang, Weiling ; Fan, Xinmin ; Chen, Si ; Yu, Huimin ; Zhao, Zhenfu ; Dong, Ming ; Liu, Jie ; Mori, Yuriko ; Meltzer, Stephen. / Aberrant methylation of the Ras-related Associated with Diabetes gene in human primary esophageal cancer. In: Anticancer Research. 2013 ; Vol. 33, No. 11. pp. 5199-5204.
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AU - Feng, Xianling

AU - Jian, Qianhe

AU - Cheng, Yulan

AU - Gao, Yan

AU - Zhang, Xiaojing

AU - Wang, Liang

AU - Zhang, Yuan

AU - Huang, Weiling

AU - Fan, Xinmin

AU - Chen, Si

AU - Yu, Huimin

AU - Zhao, Zhenfu

AU - Dong, Ming

AU - Liu, Jie

AU - Mori, Yuriko

AU - Meltzer, Stephen

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