Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample

Flor A. Espinoza, Victor M. Vergara, Daisy Reyes, Nathaniel E. Anderson, Carla L. Harenski, Jean Decety, Srinivas Rachakonda, Eswar Damaraju, Barnaly Rashid, Robyn L. Miller, Michael Koenigs, David S. Kosson, Keith Harenski, Kent A. Kiehl, Vince Daniel Calhoun

Research output: Contribution to journalArticle

Abstract

Psychopathy is a personality disorder characterized by antisocial behavior, lack of remorse and empathy, and impaired decision making. The disproportionate amount of crime committed by psychopaths has severe emotional and economic impacts on society. Here we examine the neural correlates associated with psychopathy to improve early assessment and perhaps inform treatments for this condition. Previous resting-state functional magnetic resonance imaging (fMRI) studies in psychopathy have primarily focused on regions of interest. This study examines whole-brain functional connectivity and its association to psychopathic traits. Psychopathy was hypothesized to be characterized by aberrant functional network connectivity (FNC) in several limbic/paralimbic networks. Group-independent component and regression analyses were applied to a data set of resting-state fMRI from 985 incarcerated adult males. We identified resting-state networks (RSNs), estimated FNC between RSNs, and tested their association to psychopathy factors and total summary scores (Factor 1, interpersonal/affective; Factor 2, lifestyle/antisocial). Factor 1 scores showed both increased and reduced functional connectivity between RSNs from seven brain domains (sensorimotor, cerebellar, visual, salience, default mode, executive control, and attentional). Consistent with hypotheses, RSNs from the paralimbic system-insula, anterior and posterior cingulate cortex, amygdala, orbital frontal cortex, and superior temporal gyrus-were related to Factor 1 scores. No significant FNC associations were found with Factor 2 and total PCL-R scores. In summary, results suggest that the affective and interpersonal symptoms of psychopathy (Factor 1) are associated with aberrant connectivity in multiple brain networks, including paralimbic regions.

Original languageEnglish (US)
JournalHuman Brain Mapping
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Gyrus Cinguli
Brain
Magnetic Resonance Imaging
Antisocial Personality Disorder
Affective Symptoms
Executive Function
Frontal Lobe
Crime
Temporal Lobe
Amygdala
Prefrontal Cortex
Life Style
Decision Making
Regression Analysis
Economics
Datasets

Keywords

  • Functional network connectivity
  • Group independent component analysis
  • Male inmates
  • Psychopathy
  • Resting-state fMRI

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Espinoza, F. A., Vergara, V. M., Reyes, D., Anderson, N. E., Harenski, C. L., Decety, J., ... Calhoun, V. D. (Accepted/In press). Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample. Human Brain Mapping. https://doi.org/10.1002/hbm.24028

Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample. / Espinoza, Flor A.; Vergara, Victor M.; Reyes, Daisy; Anderson, Nathaniel E.; Harenski, Carla L.; Decety, Jean; Rachakonda, Srinivas; Damaraju, Eswar; Rashid, Barnaly; Miller, Robyn L.; Koenigs, Michael; Kosson, David S.; Harenski, Keith; Kiehl, Kent A.; Calhoun, Vince Daniel.

In: Human Brain Mapping, 01.01.2018.

Research output: Contribution to journalArticle

Espinoza, FA, Vergara, VM, Reyes, D, Anderson, NE, Harenski, CL, Decety, J, Rachakonda, S, Damaraju, E, Rashid, B, Miller, RL, Koenigs, M, Kosson, DS, Harenski, K, Kiehl, KA & Calhoun, VD 2018, 'Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample', Human Brain Mapping. https://doi.org/10.1002/hbm.24028
Espinoza, Flor A. ; Vergara, Victor M. ; Reyes, Daisy ; Anderson, Nathaniel E. ; Harenski, Carla L. ; Decety, Jean ; Rachakonda, Srinivas ; Damaraju, Eswar ; Rashid, Barnaly ; Miller, Robyn L. ; Koenigs, Michael ; Kosson, David S. ; Harenski, Keith ; Kiehl, Kent A. ; Calhoun, Vince Daniel. / Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample. In: Human Brain Mapping. 2018.
@article{12a9a353ea0345ab96f7918a8cb145fd,
title = "Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample",
abstract = "Psychopathy is a personality disorder characterized by antisocial behavior, lack of remorse and empathy, and impaired decision making. The disproportionate amount of crime committed by psychopaths has severe emotional and economic impacts on society. Here we examine the neural correlates associated with psychopathy to improve early assessment and perhaps inform treatments for this condition. Previous resting-state functional magnetic resonance imaging (fMRI) studies in psychopathy have primarily focused on regions of interest. This study examines whole-brain functional connectivity and its association to psychopathic traits. Psychopathy was hypothesized to be characterized by aberrant functional network connectivity (FNC) in several limbic/paralimbic networks. Group-independent component and regression analyses were applied to a data set of resting-state fMRI from 985 incarcerated adult males. We identified resting-state networks (RSNs), estimated FNC between RSNs, and tested their association to psychopathy factors and total summary scores (Factor 1, interpersonal/affective; Factor 2, lifestyle/antisocial). Factor 1 scores showed both increased and reduced functional connectivity between RSNs from seven brain domains (sensorimotor, cerebellar, visual, salience, default mode, executive control, and attentional). Consistent with hypotheses, RSNs from the paralimbic system-insula, anterior and posterior cingulate cortex, amygdala, orbital frontal cortex, and superior temporal gyrus-were related to Factor 1 scores. No significant FNC associations were found with Factor 2 and total PCL-R scores. In summary, results suggest that the affective and interpersonal symptoms of psychopathy (Factor 1) are associated with aberrant connectivity in multiple brain networks, including paralimbic regions.",
keywords = "Functional network connectivity, Group independent component analysis, Male inmates, Psychopathy, Resting-state fMRI",
author = "Espinoza, {Flor A.} and Vergara, {Victor M.} and Daisy Reyes and Anderson, {Nathaniel E.} and Harenski, {Carla L.} and Jean Decety and Srinivas Rachakonda and Eswar Damaraju and Barnaly Rashid and Miller, {Robyn L.} and Michael Koenigs and Kosson, {David S.} and Keith Harenski and Kiehl, {Kent A.} and Calhoun, {Vince Daniel}",
year = "2018",
month = "1",
day = "1",
doi = "10.1002/hbm.24028",
language = "English (US)",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - Aberrant functional network connectivity in psychopathy from a large (N = 985) forensic sample

AU - Espinoza, Flor A.

AU - Vergara, Victor M.

AU - Reyes, Daisy

AU - Anderson, Nathaniel E.

AU - Harenski, Carla L.

AU - Decety, Jean

AU - Rachakonda, Srinivas

AU - Damaraju, Eswar

AU - Rashid, Barnaly

AU - Miller, Robyn L.

AU - Koenigs, Michael

AU - Kosson, David S.

AU - Harenski, Keith

AU - Kiehl, Kent A.

AU - Calhoun, Vince Daniel

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Psychopathy is a personality disorder characterized by antisocial behavior, lack of remorse and empathy, and impaired decision making. The disproportionate amount of crime committed by psychopaths has severe emotional and economic impacts on society. Here we examine the neural correlates associated with psychopathy to improve early assessment and perhaps inform treatments for this condition. Previous resting-state functional magnetic resonance imaging (fMRI) studies in psychopathy have primarily focused on regions of interest. This study examines whole-brain functional connectivity and its association to psychopathic traits. Psychopathy was hypothesized to be characterized by aberrant functional network connectivity (FNC) in several limbic/paralimbic networks. Group-independent component and regression analyses were applied to a data set of resting-state fMRI from 985 incarcerated adult males. We identified resting-state networks (RSNs), estimated FNC between RSNs, and tested their association to psychopathy factors and total summary scores (Factor 1, interpersonal/affective; Factor 2, lifestyle/antisocial). Factor 1 scores showed both increased and reduced functional connectivity between RSNs from seven brain domains (sensorimotor, cerebellar, visual, salience, default mode, executive control, and attentional). Consistent with hypotheses, RSNs from the paralimbic system-insula, anterior and posterior cingulate cortex, amygdala, orbital frontal cortex, and superior temporal gyrus-were related to Factor 1 scores. No significant FNC associations were found with Factor 2 and total PCL-R scores. In summary, results suggest that the affective and interpersonal symptoms of psychopathy (Factor 1) are associated with aberrant connectivity in multiple brain networks, including paralimbic regions.

AB - Psychopathy is a personality disorder characterized by antisocial behavior, lack of remorse and empathy, and impaired decision making. The disproportionate amount of crime committed by psychopaths has severe emotional and economic impacts on society. Here we examine the neural correlates associated with psychopathy to improve early assessment and perhaps inform treatments for this condition. Previous resting-state functional magnetic resonance imaging (fMRI) studies in psychopathy have primarily focused on regions of interest. This study examines whole-brain functional connectivity and its association to psychopathic traits. Psychopathy was hypothesized to be characterized by aberrant functional network connectivity (FNC) in several limbic/paralimbic networks. Group-independent component and regression analyses were applied to a data set of resting-state fMRI from 985 incarcerated adult males. We identified resting-state networks (RSNs), estimated FNC between RSNs, and tested their association to psychopathy factors and total summary scores (Factor 1, interpersonal/affective; Factor 2, lifestyle/antisocial). Factor 1 scores showed both increased and reduced functional connectivity between RSNs from seven brain domains (sensorimotor, cerebellar, visual, salience, default mode, executive control, and attentional). Consistent with hypotheses, RSNs from the paralimbic system-insula, anterior and posterior cingulate cortex, amygdala, orbital frontal cortex, and superior temporal gyrus-were related to Factor 1 scores. No significant FNC associations were found with Factor 2 and total PCL-R scores. In summary, results suggest that the affective and interpersonal symptoms of psychopathy (Factor 1) are associated with aberrant connectivity in multiple brain networks, including paralimbic regions.

KW - Functional network connectivity

KW - Group independent component analysis

KW - Male inmates

KW - Psychopathy

KW - Resting-state fMRI

UR - http://www.scopus.com/inward/record.url?scp=85042657974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042657974&partnerID=8YFLogxK

U2 - 10.1002/hbm.24028

DO - 10.1002/hbm.24028

M3 - Article

C2 - 29498761

AN - SCOPUS:85042657974

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

ER -