Aberrant expression of bcl-2 gene family in Down's syndrome brains

Akira Sawa; Fumitaka Oyama; Nigel J. Cairns; Naoji Amano; Masaaki Matsushita

doi:10.1016/S0169-328X(97)00078-8

Aberrant expression of bcl-2 gene family in Down's syndrome brains

Akira Sawa, Fumitaka Oyama, Nigel J. Cairns, Naoji Amano, Masaaki Matsushita

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Down's syndrome (DS) patient brains are known to develop prematurely the same degenerative changes as those seen in Alzheimer's disease (AD). On the assumption that the apoptotic mechanism is involved in the neuronal loss in DS, we have investigated the expression of the bcl-2 gene family in DS brains and found marked alterations. The most prominent changes were in the temporal lobes where neuronal loss was greatest. Our findings suggest that a apoptotic process is involved in the neuronal loss in DS.

Original language	English (US)
Pages (from-to)	53-59
Number of pages	7
Journal	Molecular Brain Research
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/S0169-328X(97)00078-8
State	Published - Aug 1997
Externally published	Yes

Keywords

Alzheimer's disease
Apoptosis
Bax
Bcl-2
Bcl-x
Down's syndrome

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

Access to Document

10.1016/S0169-328X(97)00078-8

Cite this

@article{a3bdddfdec524c228b752bbdbd14c1ae,

title = "Aberrant expression of bcl-2 gene family in Down's syndrome brains",

abstract = "Down's syndrome (DS) patient brains are known to develop prematurely the same degenerative changes as those seen in Alzheimer's disease (AD). On the assumption that the apoptotic mechanism is involved in the neuronal loss in DS, we have investigated the expression of the bcl-2 gene family in DS brains and found marked alterations. The most prominent changes were in the temporal lobes where neuronal loss was greatest. Our findings suggest that a apoptotic process is involved in the neuronal loss in DS.",

keywords = "Alzheimer's disease, Apoptosis, Bax, Bcl-2, Bcl-x, Down's syndrome",

author = "Akira Sawa and Fumitaka Oyama and Cairns, {Nigel J.} and Naoji Amano and Masaaki Matsushita",

note = "Funding Information: This study was partly supported by a grant from the Univers Foundation (to A.S.) and a grant-in-aid for Scientic Research on Priority Areas from the Ministry of Education, Science and Culture (Japan). We would like to express our thanks to Dr. Y. Ihara for the data about APP gene expression in DS and reading this manuscript. We would like to express our thanks to Drs. S.H. Snyder and A.A. Khan for reading this manuscript and giving us useful advice. We thank to Drs. S. Ohta and N. Inohara for their useful discussion and Mr. I. Yamamoto, Dr. R. Rao and Ms. H. Yoshida-Takahashi for their technical assistance.",

year = "1997",

month = aug,

doi = "10.1016/S0169-328X(97)00078-8",

language = "English (US)",

volume = "48",

pages = "53--59",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Aberrant expression of bcl-2 gene family in Down's syndrome brains

AU - Sawa, Akira

AU - Oyama, Fumitaka

AU - Cairns, Nigel J.

AU - Amano, Naoji

AU - Matsushita, Masaaki

N1 - Funding Information: This study was partly supported by a grant from the Univers Foundation (to A.S.) and a grant-in-aid for Scientic Research on Priority Areas from the Ministry of Education, Science and Culture (Japan). We would like to express our thanks to Dr. Y. Ihara for the data about APP gene expression in DS and reading this manuscript. We would like to express our thanks to Drs. S.H. Snyder and A.A. Khan for reading this manuscript and giving us useful advice. We thank to Drs. S. Ohta and N. Inohara for their useful discussion and Mr. I. Yamamoto, Dr. R. Rao and Ms. H. Yoshida-Takahashi for their technical assistance.

PY - 1997/8

Y1 - 1997/8

N2 - Down's syndrome (DS) patient brains are known to develop prematurely the same degenerative changes as those seen in Alzheimer's disease (AD). On the assumption that the apoptotic mechanism is involved in the neuronal loss in DS, we have investigated the expression of the bcl-2 gene family in DS brains and found marked alterations. The most prominent changes were in the temporal lobes where neuronal loss was greatest. Our findings suggest that a apoptotic process is involved in the neuronal loss in DS.

AB - Down's syndrome (DS) patient brains are known to develop prematurely the same degenerative changes as those seen in Alzheimer's disease (AD). On the assumption that the apoptotic mechanism is involved in the neuronal loss in DS, we have investigated the expression of the bcl-2 gene family in DS brains and found marked alterations. The most prominent changes were in the temporal lobes where neuronal loss was greatest. Our findings suggest that a apoptotic process is involved in the neuronal loss in DS.

KW - Alzheimer's disease

KW - Apoptosis

KW - Bax

KW - Bcl-2

KW - Bcl-x

KW - Down's syndrome

UR - http://www.scopus.com/inward/record.url?scp=0030811487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030811487&partnerID=8YFLogxK

U2 - 10.1016/S0169-328X(97)00078-8

DO - 10.1016/S0169-328X(97)00078-8

M3 - Article

C2 - 9379849

AN - SCOPUS:0030811487

VL - 48

SP - 53

EP - 59

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -

Aberrant expression of bcl-2 gene family in Down's syndrome brains

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this