Aberrant expression of bcl-2 gene family in Down's syndrome brains

Akira Sawa, Fumitaka Oyama, Nigel J. Cairns, Naoji Amano, Masaaki Matsushita

Research output: Contribution to journalArticle

Abstract

Down's syndrome (DS) patient brains are known to develop prematurely the same degenerative changes as those seen in Alzheimer's disease (AD). On the assumption that the apoptotic mechanism is involved in the neuronal loss in DS, we have investigated the expression of the bcl-2 gene family in DS brains and found marked alterations. The most prominent changes were in the temporal lobes where neuronal loss was greatest. Our findings suggest that a apoptotic process is involved in the neuronal loss in DS.

Original languageEnglish (US)
Pages (from-to)53-59
Number of pages7
JournalMolecular Brain Research
Volume48
Issue number1
DOIs
StatePublished - Aug 1 1997
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Apoptosis
  • Bax
  • Bcl-2
  • Bcl-x
  • Down's syndrome

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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