Abstract
Down's syndrome (DS) patient brains are known to develop prematurely the same degenerative changes as those seen in Alzheimer's disease (AD). On the assumption that the apoptotic mechanism is involved in the neuronal loss in DS, we have investigated the expression of the bcl-2 gene family in DS brains and found marked alterations. The most prominent changes were in the temporal lobes where neuronal loss was greatest. Our findings suggest that a apoptotic process is involved in the neuronal loss in DS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 53-59 |
| Number of pages | 7 |
| Journal | Molecular Brain Research |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 1 1997 |
| Externally published | Yes |
Keywords
- Alzheimer's disease
- Apoptosis
- Bax
- Bcl-2
- Bcl-x
- Down's syndrome
ASJC Scopus subject areas
- Molecular Biology
- Cellular and Molecular Neuroscience
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Sawa, A., Oyama, F., Cairns, N. J., Amano, N., & Matsushita, M. (1997). Aberrant expression of bcl-2 gene family in Down's syndrome brains. Molecular Brain Research, 48(1), 53-59. https://doi.org/10.1016/S0169-328X(97)00078-8