Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma

Jia Huei Tsai; Yu Lin Lin; Yi Chen Cheng; Chien Chuan Chen; Liang In Lin; Li Hui Tseng; Mei Ling Cheng; Jau Yu Liau; Yung Ming Jeng

doi:10.1038/modpathol.2014.96

Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma

Jia Huei Tsai, Yu Lin Lin, Yi Chen Cheng, Chien Chuan Chen, Liang In Lin, Li Hui Tseng, Mei Ling Cheng, Jau Yu Liau, Yung Ming Jeng

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Annexin A10 (ANXA10) is a member of the ANX family that is normally expressed in gastric mucosa. ANXA10 was recently observed to be upregulated in sessile serrated adenoma, a precursor to microsatellite-unstable colorectal cancer. We investigated the use of ANXA10 in diagnosing colorectal carcinoma. In an immunohistochemical analysis, the intensity and quantity of ANXA10, MUC5AC, MUC6 and CDX2 in 123 colorectal carcinomas were graded. We determined the molecular status of BRAF and KRAS mutations, as well as the microsatellite instability status and the CpG island methylator phenotype in all colorectal carcinomas, and subcategorized into four molecular subgroups according to the molecular derangements. Nuclear ANXA10 staining was present in 36 colorectal carcinomas, exhibiting a strong significant association with the BRAF mutation status (P

Original language	English (US)
Pages (from-to)	268-278
Number of pages	11
Journal	Modern Pathology
Volume	28
Issue number	2
DOIs	https://doi.org/10.1038/modpathol.2014.96
State	Published - Feb 2 2015
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine
General Medicine

Access to Document

10.1038/modpathol.2014.96

Cite this

@article{a47ae2130c304e089b12f2946ec152ed,

title = "Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma",

abstract = "Annexin A10 (ANXA10) is a member of the ANX family that is normally expressed in gastric mucosa. ANXA10 was recently observed to be upregulated in sessile serrated adenoma, a precursor to microsatellite-unstable colorectal cancer. We investigated the use of ANXA10 in diagnosing colorectal carcinoma. In an immunohistochemical analysis, the intensity and quantity of ANXA10, MUC5AC, MUC6 and CDX2 in 123 colorectal carcinomas were graded. We determined the molecular status of BRAF and KRAS mutations, as well as the microsatellite instability status and the CpG island methylator phenotype in all colorectal carcinomas, and subcategorized into four molecular subgroups according to the molecular derangements. Nuclear ANXA10 staining was present in 36 colorectal carcinomas, exhibiting a strong significant association with the BRAF mutation status (P",

author = "Tsai, {Jia Huei} and Lin, {Yu Lin} and Cheng, {Yi Chen} and Chen, {Chien Chuan} and Lin, {Liang In} and Tseng, {Li Hui} and Cheng, {Mei Ling} and Liau, {Jau Yu} and Jeng, {Yung Ming}",

year = "2015",

month = feb,

day = "2",

doi = "10.1038/modpathol.2014.96",

language = "English (US)",

volume = "28",

pages = "268--278",

journal = "Modern Pathology",

issn = "0893-3952",

publisher = "Nature Publishing Group",

number = "2",

}

TY - JOUR

T1 - Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma

AU - Tsai, Jia Huei

AU - Lin, Yu Lin

AU - Cheng, Yi Chen

AU - Chen, Chien Chuan

AU - Lin, Liang In

AU - Tseng, Li Hui

AU - Cheng, Mei Ling

AU - Liau, Jau Yu

AU - Jeng, Yung Ming

PY - 2015/2/2

Y1 - 2015/2/2

N2 - Annexin A10 (ANXA10) is a member of the ANX family that is normally expressed in gastric mucosa. ANXA10 was recently observed to be upregulated in sessile serrated adenoma, a precursor to microsatellite-unstable colorectal cancer. We investigated the use of ANXA10 in diagnosing colorectal carcinoma. In an immunohistochemical analysis, the intensity and quantity of ANXA10, MUC5AC, MUC6 and CDX2 in 123 colorectal carcinomas were graded. We determined the molecular status of BRAF and KRAS mutations, as well as the microsatellite instability status and the CpG island methylator phenotype in all colorectal carcinomas, and subcategorized into four molecular subgroups according to the molecular derangements. Nuclear ANXA10 staining was present in 36 colorectal carcinomas, exhibiting a strong significant association with the BRAF mutation status (P

AB - Annexin A10 (ANXA10) is a member of the ANX family that is normally expressed in gastric mucosa. ANXA10 was recently observed to be upregulated in sessile serrated adenoma, a precursor to microsatellite-unstable colorectal cancer. We investigated the use of ANXA10 in diagnosing colorectal carcinoma. In an immunohistochemical analysis, the intensity and quantity of ANXA10, MUC5AC, MUC6 and CDX2 in 123 colorectal carcinomas were graded. We determined the molecular status of BRAF and KRAS mutations, as well as the microsatellite instability status and the CpG island methylator phenotype in all colorectal carcinomas, and subcategorized into four molecular subgroups according to the molecular derangements. Nuclear ANXA10 staining was present in 36 colorectal carcinomas, exhibiting a strong significant association with the BRAF mutation status (P

UR - http://www.scopus.com/inward/record.url?scp=84922017795&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922017795&partnerID=8YFLogxK

U2 - 10.1038/modpathol.2014.96

DO - 10.1038/modpathol.2014.96

M3 - Article

C2 - 25081749

AN - SCOPUS:84922017795

SN - 0893-3952

VL - 28

SP - 268

EP - 278

JO - Modern Pathology

JF - Modern Pathology

IS - 2

ER -

Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this