TY - JOUR
T1 - Aberrant amygdala intrinsic functional connectivity distinguishes youths with bipolar disorder from those with severe mood dysregulation
AU - Stoddard, Joel
AU - Hsu, Derek
AU - Reynolds, Richard C.
AU - Brotman, Melissa A.
AU - Ernst, Monique
AU - Pine, Daniel S.
AU - Leibenluft, Ellen
AU - Dickstein, Daniel P.
N1 - Funding Information:
This research was supported by the Intramural Research Program, National Institute of Mental Health ( NIMH ). We thank the children and families who participated in this study, and the staff of the Emotion and Development Branch at NIMH.
Publisher Copyright:
© 2014.
PY - 2015/2/28
Y1 - 2015/2/28
N2 - It remains unclear the degree to which youths with episodic mania (bipolar disorder; BD) vs. those with chronic, severe irritability (severe mood dysregulation, SMD) should be placed in similar or distinct diagnostic groups. Addressing this clinically meaningful question requires greater understanding of the neural alterations underlying both disorders. We evaluated resting state functional magnetic resonance imaging data of 53 youths (14 BD, 20 healthy volunteers (HV), and 19 SMD, ages 9-18.5 years). Seed regions of interest were the bilateral basolateral, superficial and centromedial amygdala, defined using the Juelich probabilistic atlas. We found a significant between-group difference in functional connectivity between the left basolateral amygdala and the medial aspect of the left frontal pole plus the posterior cingulate/precuneus. This finding was driven by hyperconnectivity among BD vs. HV or SMD youths. As with earlier data, these findings suggest that the pathophysiology of BD and SMD may differ.
AB - It remains unclear the degree to which youths with episodic mania (bipolar disorder; BD) vs. those with chronic, severe irritability (severe mood dysregulation, SMD) should be placed in similar or distinct diagnostic groups. Addressing this clinically meaningful question requires greater understanding of the neural alterations underlying both disorders. We evaluated resting state functional magnetic resonance imaging data of 53 youths (14 BD, 20 healthy volunteers (HV), and 19 SMD, ages 9-18.5 years). Seed regions of interest were the bilateral basolateral, superficial and centromedial amygdala, defined using the Juelich probabilistic atlas. We found a significant between-group difference in functional connectivity between the left basolateral amygdala and the medial aspect of the left frontal pole plus the posterior cingulate/precuneus. This finding was driven by hyperconnectivity among BD vs. HV or SMD youths. As with earlier data, these findings suggest that the pathophysiology of BD and SMD may differ.
KW - Bipolar disorder
KW - Child
KW - Functional connectivity
KW - Irritability
KW - Magnetic resonance imaging
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U2 - 10.1016/j.pscychresns.2014.11.006
DO - 10.1016/j.pscychresns.2014.11.006
M3 - Article
C2 - 25544024
AN - SCOPUS:84922827361
SN - 0925-4927
VL - 231
SP - 120
EP - 125
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 2
ER -