Abdominal ventral hernia repair with current biological prostheses: An experimental large animal model

Matthew G. Stanwix, Arthur J. Nam, Helen G. Hui-Chou, Jonathan P. Ferrari, Harold M. Aberman, Michael L. Hawes, Kaspar M. Keledjian, Luke S. Jones, Eduardo D. Rodriguez

Research output: Contribution to journalArticle

Abstract

Biologic prostheses have emerged to address the limitations of synthetic materials for ventral hernia repairs; however, they lack experimental comparative data. Fifteen swine were randomly assigned to 1 of 3 bioprosthetic groups (DermaMatrix, AlloDerm, and Permacol) after creation of a full thickness ventral fascial defect. At 15 weeks, host incorporation, hernia recurrence, adhesion formation, neovascularization, inflammation, and biomechanical properties were assessed. No animals had hernia recurrence or eventration. DermaMatrix and Alloderm implants demonstrated more adhesions, greater inflammatory infiltration, and more longitudinal laxity, but near identical neovascularization and tensile strength to Permacol. We found that porcine acellular dermal products (Permacol) contain following essential properties of an ideal ventral hernia repair material: low inflammation, less elastin and stretch, lower adhesion rates and cost, and more contracture. The addition of lower cost xenogeneic acellular dermal products to the repertoire of available acellular dermal products demonstrates promise, but requires long-term clinical studies to verify advantages and efficacy.

Original languageEnglish (US)
Pages (from-to)403-409
Number of pages7
JournalAnnals of Plastic Surgery
Volume66
Issue number4
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

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Keywords

  • alloderm
  • animal model
  • bioprosthesis
  • dermamatrix
  • neovascularization
  • permacol
  • ventral hernia

ASJC Scopus subject areas

  • Surgery

Cite this

Stanwix, M. G., Nam, A. J., Hui-Chou, H. G., Ferrari, J. P., Aberman, H. M., Hawes, M. L., ... Rodriguez, E. D. (2011). Abdominal ventral hernia repair with current biological prostheses: An experimental large animal model. Annals of Plastic Surgery, 66(4), 403-409. https://doi.org/10.1097/SAP.0b013e3181e051ed