TY - JOUR
T1 - Abdominal ventral hernia repair with current biological prostheses
T2 - An experimental large animal model
AU - Stanwix, Matthew G.
AU - Nam, Arthur J.
AU - Hui-Chou, Helen G.
AU - Ferrari, Jonathan P.
AU - Aberman, Harold M.
AU - Hawes, Michael L.
AU - Keledjian, Kaspar M.
AU - Jones, Luke S.
AU - Rodriguez, Eduardo D.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Biologic prostheses have emerged to address the limitations of synthetic materials for ventral hernia repairs; however, they lack experimental comparative data. Fifteen swine were randomly assigned to 1 of 3 bioprosthetic groups (DermaMatrix, AlloDerm, and Permacol) after creation of a full thickness ventral fascial defect. At 15 weeks, host incorporation, hernia recurrence, adhesion formation, neovascularization, inflammation, and biomechanical properties were assessed. No animals had hernia recurrence or eventration. DermaMatrix and Alloderm implants demonstrated more adhesions, greater inflammatory infiltration, and more longitudinal laxity, but near identical neovascularization and tensile strength to Permacol. We found that porcine acellular dermal products (Permacol) contain following essential properties of an ideal ventral hernia repair material: low inflammation, less elastin and stretch, lower adhesion rates and cost, and more contracture. The addition of lower cost xenogeneic acellular dermal products to the repertoire of available acellular dermal products demonstrates promise, but requires long-term clinical studies to verify advantages and efficacy.
AB - Biologic prostheses have emerged to address the limitations of synthetic materials for ventral hernia repairs; however, they lack experimental comparative data. Fifteen swine were randomly assigned to 1 of 3 bioprosthetic groups (DermaMatrix, AlloDerm, and Permacol) after creation of a full thickness ventral fascial defect. At 15 weeks, host incorporation, hernia recurrence, adhesion formation, neovascularization, inflammation, and biomechanical properties were assessed. No animals had hernia recurrence or eventration. DermaMatrix and Alloderm implants demonstrated more adhesions, greater inflammatory infiltration, and more longitudinal laxity, but near identical neovascularization and tensile strength to Permacol. We found that porcine acellular dermal products (Permacol) contain following essential properties of an ideal ventral hernia repair material: low inflammation, less elastin and stretch, lower adhesion rates and cost, and more contracture. The addition of lower cost xenogeneic acellular dermal products to the repertoire of available acellular dermal products demonstrates promise, but requires long-term clinical studies to verify advantages and efficacy.
KW - alloderm
KW - animal model
KW - bioprosthesis
KW - dermamatrix
KW - neovascularization
KW - permacol
KW - ventral hernia
UR - http://www.scopus.com/inward/record.url?scp=79952898898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952898898&partnerID=8YFLogxK
U2 - 10.1097/SAP.0b013e3181e051ed
DO - 10.1097/SAP.0b013e3181e051ed
M3 - Article
C2 - 21042180
AN - SCOPUS:79952898898
SN - 0148-7043
VL - 66
SP - 403
EP - 409
JO - Annals of plastic surgery
JF - Annals of plastic surgery
IS - 4
ER -