Abdominal fat radiodensity, quantity and cardiometabolic risk

The Multi-Ethnic Study of Atherosclerosis

Ravi V. Shah, M. A. Allison, Joao Lima, S. A. Abbasi, A. Eisman, C. Lai, M. Jerosch-Herold, M. Budoff, V. L. Murthy

Research output: Contribution to journalArticle

Abstract

Background and aims: Fat radiodensity, as measured by fat attenuation on computed tomography (CT), has emerged as a potential biomarker of "fat quality." We sought to characterize the relationship between fat radiodensity and quantity in subcutaneous, visceral, and intermuscular fat depots, and its role in inflammation, insulin resistance, and metabolic syndrome (MetS). Methods and results: We studied 1511 individuals from the Multi-Ethnic Study of Atherosclerosis who underwent CT for measurement of regional fat distribution and radiodensity, along with biomarker assessments and adjudication of incident metabolic syndrome (MetS). Linear, logistic and Cox regression analyses were used to measure association between fat radiodensity and (1) fat quantity, (2) biomarkers of cardiometabolic dysfunction, and (3) both prevalent and incident MetS. In each fat depot, radiodensity was strongly and inversely associated with quantity (e.g., visceral fat radiodensity vs. quantity: ρ = -0.82, P <0.01). After adjustment for age, sex and race, lower visceral fat radiodensity was associated with greater C-reactive protein, leptin and insulin, but lower adiponectin (P <0.01 for all). After full adjustment for cardiovascular disease risk factors, visceral (but not subcutaneous or intermuscular) fat radiodensity was associated with prevalent MetS (OR = 0.96, 95% CI = 0.93-0.99, P = 0.01). Moreover, lower visceral fat radiodensity was associated with incident MetS after the same adjustment (HR = 0.95, 95% CI 0.93-0.98, P <0.01). However, this association became non-significant after further adjustment for visceral fat quantity. Conclusion: Fat radiodensity is strongly correlated with fat quantity and relevant inflammatory biomarkers. Fat radiodensity (especially for visceral fat) may be a complementary, easily assessed marker of cardiometabolic risk.

Original languageEnglish (US)
Pages (from-to)114-122
Number of pages9
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume26
Issue number2
DOIs
StatePublished - Feb 1 2016

Fingerprint

Abdominal Fat
Atherosclerosis
Fats
Intra-Abdominal Fat
Biomarkers
Tomography
Adiponectin
Leptin
C-Reactive Protein
Insulin Resistance
Cardiovascular Diseases
Logistic Models

Keywords

  • Adiponectin
  • Adiposity
  • C-reactive protein
  • Insulin
  • Metabolic syndrome
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Abdominal fat radiodensity, quantity and cardiometabolic risk : The Multi-Ethnic Study of Atherosclerosis. / Shah, Ravi V.; Allison, M. A.; Lima, Joao; Abbasi, S. A.; Eisman, A.; Lai, C.; Jerosch-Herold, M.; Budoff, M.; Murthy, V. L.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 26, No. 2, 01.02.2016, p. 114-122.

Research output: Contribution to journalArticle

Shah, Ravi V. ; Allison, M. A. ; Lima, Joao ; Abbasi, S. A. ; Eisman, A. ; Lai, C. ; Jerosch-Herold, M. ; Budoff, M. ; Murthy, V. L. / Abdominal fat radiodensity, quantity and cardiometabolic risk : The Multi-Ethnic Study of Atherosclerosis. In: Nutrition, Metabolism and Cardiovascular Diseases. 2016 ; Vol. 26, No. 2. pp. 114-122.
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AU - Abbasi, S. A.

AU - Eisman, A.

AU - Lai, C.

AU - Jerosch-Herold, M.

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