Abbreviated quantitative UTE imaging in anterior cruciate ligament reconstruction

Takeshi Fukuda, Kenneth Wengler, Dharmesh Tank, Seth Korbin, James M. Paci, David E. Komatsu, Megan Paulus, Mingqian Huang, Elaine Gould, Mark E. Schweitzer, Xiang He

Research output: Contribution to journalArticle

Abstract

Background: Existing ultrashort echo time magnetic resonance imaging (UTE MRI) methods require prohibitively long acquisition times (~ 20-40 min) to quantitatively assess the clinically relevant fast decay T2 component in ligaments and tendons. The purpose of this study was to evaluate the feasibility and clinical translatability of a novel abbreviated quantitative UTE MRI paradigm for monitoring graft remodeling after anterior cruciate ligament (ACL) reconstruction. Methods: Eight patients who had Graftlink™ hamstring autograft reconstruction were recruited for this prospective study. A 3D double-echo UTE sequence at 3.0 Tesla was performed at 3- and 6-months post-surgery. An abbreviated UTE MRI paradigm was established based on numerical simulations and in vivo validation from healthy knees. This proposed approach was used to assess the T2 for fast decay component (T 2 s {T}-{2s}^{\ast } and bound water signal fraction (f bw ) of ACL graft in regions of interest drawn by a radiologist. Results: Compared to the conventional bi-exponential model, the abbreviated UTE MRI paradigm achieved low relative estimation bias for T 2 s {T}-{2s}^{\ast } and f bw over a range of clinically relevant values for ACL grafts. A decrease in T 2 s {T}-{2s}^{\ast } of the intra-articular graft was observed in 7 of the 8 ACL reconstruction patients from 3- to 6-months (- 0.11 ± 0.16 ms, P = 0.10). Increases in T 2 s {T}-{2s} and f bw from 3- to 6-months were observed in the tibial intra-bone graft (ΔT 2 s {\varDelta T}-{2s}^{\ast } : 0.19 ± 0.18 ms, P < 0.05; Δf bw : 4% ± 4%, P < 0.05). Lower T 2 s {T}-{2s}^{\ast } (- 0.09 ± 0.11 ms, P < 0.05) was observed at 3-months when comparing the intra-bone graft to the graft/bone interface in the femoral tunnel. The same comparisons at the 6-months also yielded relatively lower T 2 s {T}-{2s} 0.09 ± 0.12 ms, P < 0.05). Conclusion: The proposed abbreviated 3D UTE MRI paradigm is capable of assessing the ACL graft remodeling process in a clinically translatable acquisition time. Longitudinal changes in T 2 s {T}-{2s}^{\ast } and f bw of the ACL graft were observed.

Original languageEnglish (US)
Article number426
JournalBMC Musculoskeletal Disorders
Volume20
Issue number1
DOIs
StatePublished - Sep 14 2019

Fingerprint

Anterior Cruciate Ligament Reconstruction
Transplants
Anterior Cruciate Ligament
Magnetic Resonance Imaging
Bone and Bones
Autografts
Thigh
Ligaments
Tendons
Knee
Joints
Prospective Studies
Water

Keywords

  • ACL reconstruction
  • Anterior cruciate ligament (ACL)
  • Graft healing
  • Ligamentization
  • Tendon-to-bone healing
  • Ultrashort TE (UTE)

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine

Cite this

Abbreviated quantitative UTE imaging in anterior cruciate ligament reconstruction. / Fukuda, Takeshi; Wengler, Kenneth; Tank, Dharmesh; Korbin, Seth; Paci, James M.; Komatsu, David E.; Paulus, Megan; Huang, Mingqian; Gould, Elaine; Schweitzer, Mark E.; He, Xiang.

In: BMC Musculoskeletal Disorders, Vol. 20, No. 1, 426, 14.09.2019.

Research output: Contribution to journalArticle

Fukuda, T, Wengler, K, Tank, D, Korbin, S, Paci, JM, Komatsu, DE, Paulus, M, Huang, M, Gould, E, Schweitzer, ME & He, X 2019, 'Abbreviated quantitative UTE imaging in anterior cruciate ligament reconstruction', BMC Musculoskeletal Disorders, vol. 20, no. 1, 426. https://doi.org/10.1186/s12891-019-2811-x
Fukuda, Takeshi ; Wengler, Kenneth ; Tank, Dharmesh ; Korbin, Seth ; Paci, James M. ; Komatsu, David E. ; Paulus, Megan ; Huang, Mingqian ; Gould, Elaine ; Schweitzer, Mark E. ; He, Xiang. / Abbreviated quantitative UTE imaging in anterior cruciate ligament reconstruction. In: BMC Musculoskeletal Disorders. 2019 ; Vol. 20, No. 1.
@article{ec98094e0a2544bb8c2b58cc2fb39810,
title = "Abbreviated quantitative UTE imaging in anterior cruciate ligament reconstruction",
abstract = "Background: Existing ultrashort echo time magnetic resonance imaging (UTE MRI) methods require prohibitively long acquisition times (~ 20-40 min) to quantitatively assess the clinically relevant fast decay T2 component in ligaments and tendons. The purpose of this study was to evaluate the feasibility and clinical translatability of a novel abbreviated quantitative UTE MRI paradigm for monitoring graft remodeling after anterior cruciate ligament (ACL) reconstruction. Methods: Eight patients who had Graftlink™ hamstring autograft reconstruction were recruited for this prospective study. A 3D double-echo UTE sequence at 3.0 Tesla was performed at 3- and 6-months post-surgery. An abbreviated UTE MRI paradigm was established based on numerical simulations and in vivo validation from healthy knees. This proposed approach was used to assess the T2 for fast decay component (T 2 s {T}-{2s}^{\ast } and bound water signal fraction (f bw ) of ACL graft in regions of interest drawn by a radiologist. Results: Compared to the conventional bi-exponential model, the abbreviated UTE MRI paradigm achieved low relative estimation bias for T 2 s {T}-{2s}^{\ast } and f bw over a range of clinically relevant values for ACL grafts. A decrease in T 2 s {T}-{2s}^{\ast } of the intra-articular graft was observed in 7 of the 8 ACL reconstruction patients from 3- to 6-months (- 0.11 ± 0.16 ms, P = 0.10). Increases in T 2 s {T}-{2s} and f bw from 3- to 6-months were observed in the tibial intra-bone graft (ΔT 2 s {\varDelta T}-{2s}^{\ast } : 0.19 ± 0.18 ms, P < 0.05; Δf bw : 4{\%} ± 4{\%}, P < 0.05). Lower T 2 s {T}-{2s}^{\ast } (- 0.09 ± 0.11 ms, P < 0.05) was observed at 3-months when comparing the intra-bone graft to the graft/bone interface in the femoral tunnel. The same comparisons at the 6-months also yielded relatively lower T 2 s {T}-{2s} 0.09 ± 0.12 ms, P < 0.05). Conclusion: The proposed abbreviated 3D UTE MRI paradigm is capable of assessing the ACL graft remodeling process in a clinically translatable acquisition time. Longitudinal changes in T 2 s {T}-{2s}^{\ast } and f bw of the ACL graft were observed.",
keywords = "ACL reconstruction, Anterior cruciate ligament (ACL), Graft healing, Ligamentization, Tendon-to-bone healing, Ultrashort TE (UTE)",
author = "Takeshi Fukuda and Kenneth Wengler and Dharmesh Tank and Seth Korbin and Paci, {James M.} and Komatsu, {David E.} and Megan Paulus and Mingqian Huang and Elaine Gould and Schweitzer, {Mark E.} and Xiang He",
year = "2019",
month = "9",
day = "14",
doi = "10.1186/s12891-019-2811-x",
language = "English (US)",
volume = "20",
journal = "BMC Musculoskeletal Disorders",
issn = "1471-2474",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Abbreviated quantitative UTE imaging in anterior cruciate ligament reconstruction

AU - Fukuda, Takeshi

AU - Wengler, Kenneth

AU - Tank, Dharmesh

AU - Korbin, Seth

AU - Paci, James M.

AU - Komatsu, David E.

AU - Paulus, Megan

AU - Huang, Mingqian

AU - Gould, Elaine

AU - Schweitzer, Mark E.

AU - He, Xiang

PY - 2019/9/14

Y1 - 2019/9/14

N2 - Background: Existing ultrashort echo time magnetic resonance imaging (UTE MRI) methods require prohibitively long acquisition times (~ 20-40 min) to quantitatively assess the clinically relevant fast decay T2 component in ligaments and tendons. The purpose of this study was to evaluate the feasibility and clinical translatability of a novel abbreviated quantitative UTE MRI paradigm for monitoring graft remodeling after anterior cruciate ligament (ACL) reconstruction. Methods: Eight patients who had Graftlink™ hamstring autograft reconstruction were recruited for this prospective study. A 3D double-echo UTE sequence at 3.0 Tesla was performed at 3- and 6-months post-surgery. An abbreviated UTE MRI paradigm was established based on numerical simulations and in vivo validation from healthy knees. This proposed approach was used to assess the T2 for fast decay component (T 2 s {T}-{2s}^{\ast } and bound water signal fraction (f bw ) of ACL graft in regions of interest drawn by a radiologist. Results: Compared to the conventional bi-exponential model, the abbreviated UTE MRI paradigm achieved low relative estimation bias for T 2 s {T}-{2s}^{\ast } and f bw over a range of clinically relevant values for ACL grafts. A decrease in T 2 s {T}-{2s}^{\ast } of the intra-articular graft was observed in 7 of the 8 ACL reconstruction patients from 3- to 6-months (- 0.11 ± 0.16 ms, P = 0.10). Increases in T 2 s {T}-{2s} and f bw from 3- to 6-months were observed in the tibial intra-bone graft (ΔT 2 s {\varDelta T}-{2s}^{\ast } : 0.19 ± 0.18 ms, P < 0.05; Δf bw : 4% ± 4%, P < 0.05). Lower T 2 s {T}-{2s}^{\ast } (- 0.09 ± 0.11 ms, P < 0.05) was observed at 3-months when comparing the intra-bone graft to the graft/bone interface in the femoral tunnel. The same comparisons at the 6-months also yielded relatively lower T 2 s {T}-{2s} 0.09 ± 0.12 ms, P < 0.05). Conclusion: The proposed abbreviated 3D UTE MRI paradigm is capable of assessing the ACL graft remodeling process in a clinically translatable acquisition time. Longitudinal changes in T 2 s {T}-{2s}^{\ast } and f bw of the ACL graft were observed.

AB - Background: Existing ultrashort echo time magnetic resonance imaging (UTE MRI) methods require prohibitively long acquisition times (~ 20-40 min) to quantitatively assess the clinically relevant fast decay T2 component in ligaments and tendons. The purpose of this study was to evaluate the feasibility and clinical translatability of a novel abbreviated quantitative UTE MRI paradigm for monitoring graft remodeling after anterior cruciate ligament (ACL) reconstruction. Methods: Eight patients who had Graftlink™ hamstring autograft reconstruction were recruited for this prospective study. A 3D double-echo UTE sequence at 3.0 Tesla was performed at 3- and 6-months post-surgery. An abbreviated UTE MRI paradigm was established based on numerical simulations and in vivo validation from healthy knees. This proposed approach was used to assess the T2 for fast decay component (T 2 s {T}-{2s}^{\ast } and bound water signal fraction (f bw ) of ACL graft in regions of interest drawn by a radiologist. Results: Compared to the conventional bi-exponential model, the abbreviated UTE MRI paradigm achieved low relative estimation bias for T 2 s {T}-{2s}^{\ast } and f bw over a range of clinically relevant values for ACL grafts. A decrease in T 2 s {T}-{2s}^{\ast } of the intra-articular graft was observed in 7 of the 8 ACL reconstruction patients from 3- to 6-months (- 0.11 ± 0.16 ms, P = 0.10). Increases in T 2 s {T}-{2s} and f bw from 3- to 6-months were observed in the tibial intra-bone graft (ΔT 2 s {\varDelta T}-{2s}^{\ast } : 0.19 ± 0.18 ms, P < 0.05; Δf bw : 4% ± 4%, P < 0.05). Lower T 2 s {T}-{2s}^{\ast } (- 0.09 ± 0.11 ms, P < 0.05) was observed at 3-months when comparing the intra-bone graft to the graft/bone interface in the femoral tunnel. The same comparisons at the 6-months also yielded relatively lower T 2 s {T}-{2s} 0.09 ± 0.12 ms, P < 0.05). Conclusion: The proposed abbreviated 3D UTE MRI paradigm is capable of assessing the ACL graft remodeling process in a clinically translatable acquisition time. Longitudinal changes in T 2 s {T}-{2s}^{\ast } and f bw of the ACL graft were observed.

KW - ACL reconstruction

KW - Anterior cruciate ligament (ACL)

KW - Graft healing

KW - Ligamentization

KW - Tendon-to-bone healing

KW - Ultrashort TE (UTE)

UR - http://www.scopus.com/inward/record.url?scp=85072209225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072209225&partnerID=8YFLogxK

U2 - 10.1186/s12891-019-2811-x

DO - 10.1186/s12891-019-2811-x

M3 - Article

VL - 20

JO - BMC Musculoskeletal Disorders

JF - BMC Musculoskeletal Disorders

SN - 1471-2474

IS - 1

M1 - 426

ER -