TY - JOUR
T1 - A yeast by any other name
T2 - Candida glabrata and its interaction with the host
AU - Kaur, Rupinder
AU - Domergue, Renee
AU - Zupancic, Margaret L.
AU - Cormack, Brendan P.
PY - 2005/8
Y1 - 2005/8
N2 - Well-characterized traits important to Candida albicans virulence, such as hyphal formation or secreted proteinase activity, play no known role in Candida glabrata virulence. Likewise, some C. glabrata characteristics, such as chromatin-based regulation of the large telomeric family of lectins encoded by the EPA (epithelial adhesin) genes, have no precise parallels in C. albicans. However, similarities between the two species, for example in population structure, in the large numbers of (putative) adhesins that they encode, and in phenotypic plasticity conferred by phenotypic switching, suggest that they share general strategies in adaptation to an opportunistic lifestyle.
AB - Well-characterized traits important to Candida albicans virulence, such as hyphal formation or secreted proteinase activity, play no known role in Candida glabrata virulence. Likewise, some C. glabrata characteristics, such as chromatin-based regulation of the large telomeric family of lectins encoded by the EPA (epithelial adhesin) genes, have no precise parallels in C. albicans. However, similarities between the two species, for example in population structure, in the large numbers of (putative) adhesins that they encode, and in phenotypic plasticity conferred by phenotypic switching, suggest that they share general strategies in adaptation to an opportunistic lifestyle.
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U2 - 10.1016/j.mib.2005.06.012
DO - 10.1016/j.mib.2005.06.012
M3 - Review article
C2 - 15996895
AN - SCOPUS:22544444651
SN - 1369-5274
VL - 8
SP - 378
EP - 384
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 4
ER -