A year of unprecedented progress in down syndrome basic research

Roger H. Reeves, Craig C. Garner

Research output: Contribution to journalReview articlepeer-review


The years 2006 and 2007 saw the publication of three new and different approaches to prevention or amelioration of Down syndrome effects on the brain and cognition. We describe the animal model systems that were critical to this progress, review these independent breakthrough studies, and discuss the implications for therapeutic approaches suggested by each.

Original languageEnglish (US)
Pages (from-to)215-220
Number of pages6
JournalMental Retardation and Developmental Disabilities Research Reviews
Issue number3
StatePublished - 2007


  • APP
  • Brain development
  • Cognitive testing
  • GABA inhibitor
  • Mouse model
  • Sonic hedgehog
  • Synapse function

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neuropsychology and Physiological Psychology
  • Genetics(clinical)


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