A year of unprecedented progress in down syndrome basic research

Roger H. Reeves; Craig C. Garner

doi:10.1002/mrdd.20165

A year of unprecedented progress in down syndrome basic research

Roger H. Reeves, Craig C. Garner

School of Medicine

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

The years 2006 and 2007 saw the publication of three new and different approaches to prevention or amelioration of Down syndrome effects on the brain and cognition. We describe the animal model systems that were critical to this progress, review these independent breakthrough studies, and discuss the implications for therapeutic approaches suggested by each.

Original language	English (US)
Pages (from-to)	215-220
Number of pages	6
Journal	Mental Retardation and Developmental Disabilities Research Reviews
Volume	13
Issue number	3
DOIs	https://doi.org/10.1002/mrdd.20165
State	Published - 2007

Keywords

APP
Brain development
Cognitive testing
GABA inhibitor
Mouse model
Sonic hedgehog
Synapse function

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Neuropsychology and Physiological Psychology
Genetics(clinical)

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10.1002/mrdd.20165

Cite this

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KW - Sonic hedgehog

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A year of unprecedented progress in down syndrome basic research

Abstract

Keywords

ASJC Scopus subject areas

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