A workshop on measuring the progression of atrophy secondary to stargardt disease in the progstar studies: Findings and lessons learned

ProgStar Study Group

Research output: Contribution to journalArticle

Abstract

The Progression of Atrophy Secondary to Stargardt Disease (ProgStar) studies were designed to measure the progression of Stargardt disease through the use of fundus autofluorescence imaging, optical coherence tomography, and microperimetry. The overarching objectives of the studies were to document the natural course of Stargardt disease and identify the most appropriate clinical outcome measures for clinical trials assessing the efficacy and safety of upcoming treatments for Stargardt disease. A workshop organized by the Foundation Fighting Blindness Clinical Research Institute was held on June 11, 2018, in Baltimore, MD, USA. Invited speakers discussed spectral-domain optical coherence tomography, fundus autofluorescence, and microperimetry methods and findings in the ProgStar prospective study. The workshop concluded with a panel discussion of optimal endpoints for measuring treatment efficacy in Stargardt disease. We summarize the workshop presentations in light of the most current literature on Stargardt disease and discuss potential clinical outcome measures and endpoints for future treatment trials.

Original languageEnglish (US)
Article number16
JournalTranslational Vision Science and Technology
Volume8
Issue number2
DOIs
StatePublished - Mar 2019

Keywords

  • Fundus autofluorescence
  • Microperimetry
  • Natural history
  • Optical coherence tomography
  • Stargardt

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology

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