A Wnt-er Wonderland - The complexity of Wnt signaling in melanoma

Research output: Contribution to journalReview article

Abstract

Wnt signaling is a complex process that requires the interplay of several different proteins. In addition to a large cohort of Wnt ligands, and frizzled receptors, some Wnt pathways also require the presence of co-receptors. Wnt ligands may activate one of three pathways, the canonical pathway, involving β-catenin, the planar cell polarity pathway and the Wnt/ calcium pathway. All three pathways have different results for the cells in which they signal. Aberrant activation of these pathways can lead to the development and progression of several cancers. In this review we will discuss the different Wnt pathways, and their contribution to melanoma progression.

Original languageEnglish (US)
Pages (from-to)237-250
Number of pages14
JournalCancer and Metastasis Reviews
Volume24
Issue number2
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

Keywords

  • Frizzled
  • Jnk
  • Melanoma
  • Wnt
  • Wnt5a
  • β-catenin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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