A Wnt-er migration: The confusing role of β-catenin in melanoma metastasis

Wnt signaling in melanoma is complex, requiring the coordinate expression of multiple players. Depending on the context of receptors and co-receptors that are present, Wnt proteins may signal through either canonical or noncanonical pathways. The role of β-catenin in melanoma metastasis remains unclear; however, a new study points to the roles of Wnt5A and ARF6 in driving β-catenin expression and melanoma metastasis. Here, we discuss this fi nding and how it may help us defi ne different subpopulations of melanoma cells that could have different outcomes, as well as different responses to therapy.