TY - JOUR
T1 - A Wnt-er migration
T2 - The confusing role of β-catenin in melanoma metastasis
AU - Webster, Marie R.
AU - Weeraratna, Ashani T.
PY - 2013/3/26
Y1 - 2013/3/26
N2 - Wnt signaling in melanoma is complex, requiring the coordinate expression of multiple players. Depending on the context of receptors and co-receptors that are present, Wnt proteins may signal through either canonical or noncanonical pathways. The role of β-catenin in melanoma metastasis remains unclear; however, a new study points to the roles of Wnt5A and ARF6 in driving β-catenin expression and melanoma metastasis. Here, we discuss this fi nding and how it may help us defi ne different subpopulations of melanoma cells that could have different outcomes, as well as different responses to therapy.
AB - Wnt signaling in melanoma is complex, requiring the coordinate expression of multiple players. Depending on the context of receptors and co-receptors that are present, Wnt proteins may signal through either canonical or noncanonical pathways. The role of β-catenin in melanoma metastasis remains unclear; however, a new study points to the roles of Wnt5A and ARF6 in driving β-catenin expression and melanoma metastasis. Here, we discuss this fi nding and how it may help us defi ne different subpopulations of melanoma cells that could have different outcomes, as well as different responses to therapy.
UR - http://www.scopus.com/inward/record.url?scp=84875743289&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875743289&partnerID=8YFLogxK
U2 - 10.1126/scisignal.2004114
DO - 10.1126/scisignal.2004114
M3 - Review article
C2 - 23532332
AN - SCOPUS:84875743289
VL - 6
SP - pe11
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
SN - 1937-9145
IS - 268
ER -