A wearable potentiometric sensor with integrated salt bridge for sweat chloride measurement

Dong Hoon Choi, Yi Li, Garry R. Cutting, Peter C. Searson

Research output: Contribution to journalArticlepeer-review

Abstract

The development of wearable sensors to measure biomarkers in sweat remains a major technological challenge. Here we report on a wearable, potentiometric, thin film sweat chloride sensor. Potentiometric devices provide a relatively simple technology for sweat sensing, however, equilibration between the reference and test solutions is a significant source of error. We have developed a sweat chloride sensor with integrated salt bridge that minimizes equilibration and enables stable measurements over extended periods of time. The sensor shows a very small concentration drift even with small sample volumes. The measurement variation was less than 2 mM at low chloride ion concentration (10 mM) and 5 mM at high concentration (150 mM), spanning the range for healthy individuals and CF patients. Finally, in on-body tests we show that the sweat chloride concentration in healthy individuals is dependent on exercise intensity, indicating that the sensor has a potential for a fitness monitoring applications.

Original languageEnglish (US)
Pages (from-to)673-678
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume250
DOIs
StatePublished - 2017

Keywords

  • Cystic fibrosis
  • Potentiometric sensor
  • Sweat chloride
  • Wearable sensor

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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