A vulnerable interval for cerebral injury—comparison of hypothermic circulatory arrest and low flow cardiopulmonary bypass

Craig K. Mezrow, Peter S. Midulla, Ali M. Sadeghi, Otto Dapunt, Alejandro Gandsas, Howard Shiang, David A. D'alessandro, Randall B. Griepp

Research output: Contribution to journalArticlepeer-review

Abstract

Over the past two decades, advances in equipment used for cardiopulmonary bypass and in operative techniques have resulted in a tremendous decrease in the mortality of patients undergoing surgical repair of congenital heart disease utilizing hypothermic circulatory arrest. Despite the widespread use of hypothermic arrest, opinion is not unanimous with regard to its safety. Previous studies which have examined neurological outcome following repair of congenital heart disease in infancy have generally agreed that when the period of arrest exceeds 60 minutes, there is increasing risk of cerebral injury.

Original languageEnglish (US)
Pages (from-to)287-298
Number of pages12
JournalCardiology in the young
Volume3
Issue number3
DOIs
StatePublished - Jul 1993
Externally publishedYes

Keywords

  • Cerebral metabolism
  • hypothermic circulatory arrest
  • low flow bypass

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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