TY - JOUR
T1 - A virus-based vaccine may prevent cervical cancer
AU - Gravitt, Patti E.
AU - Shah, Keerti V.
PY - 2005/3
Y1 - 2005/3
N2 - High-risk human papillomaviruses (HPVs) are now recognized as the etiologic agents of invasive cervical cancer, a major cancer in women. A single HPV type (type 16) is responsible for about 50% of the cancers. The major capsid protein of papillomaviruses, LI, when expressed by recombinant DNA technology, has the intrisic ability to assemble into virus-like particles (VLPs). In a recent study, a vaccine based on HPV 16 VLPs was tested in a placebo-controlled proof-of-principle trial in young women in the United States. The vaccine was found to prevent 100% of incident persistent HPV 16 infections and HPV 16-associated cervical intraepithelial neoplasia. These results offer promise that cervical cancer will be preventable by an HPV-based vaccine. Studies planned or in progress are examining the efficacy of the vaccine in men, in HIV-infected individual, and in other parts of the world. Attempts are being made to prepare vaccines that can be administered more easily to large populations.
AB - High-risk human papillomaviruses (HPVs) are now recognized as the etiologic agents of invasive cervical cancer, a major cancer in women. A single HPV type (type 16) is responsible for about 50% of the cancers. The major capsid protein of papillomaviruses, LI, when expressed by recombinant DNA technology, has the intrisic ability to assemble into virus-like particles (VLPs). In a recent study, a vaccine based on HPV 16 VLPs was tested in a placebo-controlled proof-of-principle trial in young women in the United States. The vaccine was found to prevent 100% of incident persistent HPV 16 infections and HPV 16-associated cervical intraepithelial neoplasia. These results offer promise that cervical cancer will be preventable by an HPV-based vaccine. Studies planned or in progress are examining the efficacy of the vaccine in men, in HIV-infected individual, and in other parts of the world. Attempts are being made to prepare vaccines that can be administered more easily to large populations.
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U2 - 10.1007/s11908-005-0072-3
DO - 10.1007/s11908-005-0072-3
M3 - Review article
AN - SCOPUS:17044411344
SN - 1523-3847
VL - 7
SP - 125
EP - 131
JO - Current Infectious Disease Reports
JF - Current Infectious Disease Reports
IS - 2
ER -