A virion-specific inhibitory molecule with therapeutic potential for human immunodeficiency virus type 1

Zene Matsuda, Xiaofang Yu, Qian Chun Yu, Tun Hou Lee, Max Essex

Research output: Contribution to journalArticle

Abstract

A potential new approach for gene therapy against human immunodeficiency virus type 1 (HIV-1) infection is the design of a nonstructural gene-based virion-specific inhibitory molecule that is packaged with virus to destroy its infectivity. We tested this approach for HIV-1 by using Vpx, a virion-associated protein of HIV-2 and simian immunodeficiency virus. Vpx was incorporated into HIV-1 virions and the resulting cell-free virus lost infectivity in CD4+ human T cells. This demonstrates the therapeutic potential of an accessory gene-based virion-specific inhibitory molecule. Vpx and its derivatives can be regarded as a new class of anti-HIV-1 molecule.

Original languageEnglish (US)
Pages (from-to)3544-3548
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume90
Issue number8
DOIs
StatePublished - Apr 15 1993

Keywords

  • AIDS
  • Antiretroviral therapy
  • Vpx protein

ASJC Scopus subject areas

  • General

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