A versatile approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from L-(-)-Quebrachitol

Lixin Qiao, Youhong Hu, Fajun Nan, Garth Powis, Alan P. Kozikowski

Research output: Contribution to journalArticlepeer-review

Abstract

(matrix presented) PI(3,4)P2 R1 = R2 = PO3H2, R3 = H ; L-(-)-quebrachitol PI(4,5)P2 R1 = H, R2 = R3 = PO3H2 ; PI(3,4,5)P3 R1 = R2 = R3 = PO3H2 ; A versatile synthesis of PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 is disclosed, starting from L-(-)-quebrachitol, a byproduct of latex production. The crystalline nature of most intermediates and the utilization of inexpensive protecting groups facilitate this synthetic route and its scale-up.

Original languageEnglish (US)
Pages (from-to)115-117
Number of pages3
JournalOrganic Letters
Volume2
Issue number2
DOIs
StatePublished - Jan 27 2000

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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