TY - JOUR
T1 - A variety of cytokines and immunologically relevant surface molecules are expressed by normal human skeletal muscle cells under proinflammatory stimuli
AU - Nagaraju, K.
AU - Raben, N.
AU - Merritt, G.
AU - Loeffler, L.
AU - Kirk, K.
AU - Plotz, P.
PY - 1998
Y1 - 1998
N2 - Muscle is an attractive target for gene therapy and for immunization with DNA vaccines and is also the target of immunological injury in myositis. It is important therefore to understand the immunologic capabilities of muscle cells themselves. In this study, we show that proinflammatory stimuli induce the expression of other cytokines such as IL-6, transforming growth factor-beta (TGF-β), and granulocyte-macrophage colony-stimulating factor (GM-CSF) by muscle cells themselves, as well as the up-regulation of human leucocyte antigen (HLA) class I, class II and intercellular adhesion molecule-1 (ICAM-1). Thus, muscle cells have an inherent ability to express and respond to a variety of cytokines and chemokines. The levels of HLA class I, class II and ICAM-1 in inflamed muscle may be affected by the secreted products of the stimulation.
AB - Muscle is an attractive target for gene therapy and for immunization with DNA vaccines and is also the target of immunological injury in myositis. It is important therefore to understand the immunologic capabilities of muscle cells themselves. In this study, we show that proinflammatory stimuli induce the expression of other cytokines such as IL-6, transforming growth factor-beta (TGF-β), and granulocyte-macrophage colony-stimulating factor (GM-CSF) by muscle cells themselves, as well as the up-regulation of human leucocyte antigen (HLA) class I, class II and intercellular adhesion molecule-1 (ICAM-1). Thus, muscle cells have an inherent ability to express and respond to a variety of cytokines and chemokines. The levels of HLA class I, class II and ICAM-1 in inflamed muscle may be affected by the secreted products of the stimulation.
KW - Chemokines
KW - Cytokines
KW - Human skeletal muscle cells
KW - Proinflammatory stimuli
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U2 - 10.1046/j.1365-2249.1998.00664.x
DO - 10.1046/j.1365-2249.1998.00664.x
M3 - Article
C2 - 9737670
AN - SCOPUS:0031660980
SN - 0009-9104
VL - 113
SP - 407
EP - 414
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
IS - 3
ER -