A validated method of labial minor salivary gland biopsy for the diagnosis of Sjögren's syndrome

Jean Kim, Daniel Sun, Rebecca Ozl, Thomas Grader Beck, Julius Birnbaum, Esen K Akpek, Alan Baer

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives/Hypothesis: To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). Study Design: Prospective cohort study. Methods: Clinical data were prospectively obtained pre- and postbiopsy using patient-reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established criteria to determine the focus score. Data were analyzed using cross-tabulations. Results: Among the 58 patients in the study, 52 (90%) presented with sicca symptoms of dry eyes and/or mouth. Eight patients (14%) had histopathologic findings supportive of a diagnosis of SS. At 1 month postbiopsy, greater than 71% of patients denied any complaints of pain, swelling, numbness. or tingling. Sixteen patients (28%) had only a minor level of complaints. Only one patient complained of severe numbness at the biopsy site. Greater than 70% of patients would consider rebiopsy after the procedure, if requested by their physician. Conclusions: We present a safe and effective method of LSGB for the diagnosis of SS. Level of Evidence: 4 Laryngoscope, 126:2041–2046, 2016.

Original languageEnglish (US)
Pages (from-to)2041-2046
Number of pages6
JournalLaryngoscope
Volume126
Issue number9
DOIs
StatePublished - Sep 1 2016

Keywords

  • Labial salivary gland biopsy
  • sicca
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Medicine(all)
  • Otorhinolaryngology

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