Abstract
Objectives/Hypothesis: To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). Study Design: Prospective cohort study. Methods: Clinical data were prospectively obtained pre- and postbiopsy using patient-reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established criteria to determine the focus score. Data were analyzed using cross-tabulations. Results: Among the 58 patients in the study, 52 (90%) presented with sicca symptoms of dry eyes and/or mouth. Eight patients (14%) had histopathologic findings supportive of a diagnosis of SS. At 1 month postbiopsy, greater than 71% of patients denied any complaints of pain, swelling, numbness. or tingling. Sixteen patients (28%) had only a minor level of complaints. Only one patient complained of severe numbness at the biopsy site. Greater than 70% of patients would consider rebiopsy after the procedure, if requested by their physician. Conclusions: We present a safe and effective method of LSGB for the diagnosis of SS. Level of Evidence: 4 Laryngoscope, 126:2041–2046, 2016.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2041-2046 |
| Number of pages | 6 |
| Journal | Laryngoscope |
| Volume | 126 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2016 |
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Keywords
- Labial salivary gland biopsy
- sicca
- Sjögren's syndrome
ASJC Scopus subject areas
- Medicine(all)
- Otorhinolaryngology
Cite this
A validated method of labial minor salivary gland biopsy for the diagnosis of Sjögren's syndrome. / Kim, Jean; Sun, Daniel; Ozl, Rebecca; Grader Beck, Thomas; Birnbaum, Julius; Akpek, Esen K; Baer, Alan.
In: Laryngoscope, Vol. 126, No. 9, 01.09.2016, p. 2041-2046.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A validated method of labial minor salivary gland biopsy for the diagnosis of Sjögren's syndrome
AU - Kim, Jean
AU - Sun, Daniel
AU - Ozl, Rebecca
AU - Grader Beck, Thomas
AU - Birnbaum, Julius
AU - Akpek, Esen K
AU - Baer, Alan
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Objectives/Hypothesis: To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). Study Design: Prospective cohort study. Methods: Clinical data were prospectively obtained pre- and postbiopsy using patient-reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established criteria to determine the focus score. Data were analyzed using cross-tabulations. Results: Among the 58 patients in the study, 52 (90%) presented with sicca symptoms of dry eyes and/or mouth. Eight patients (14%) had histopathologic findings supportive of a diagnosis of SS. At 1 month postbiopsy, greater than 71% of patients denied any complaints of pain, swelling, numbness. or tingling. Sixteen patients (28%) had only a minor level of complaints. Only one patient complained of severe numbness at the biopsy site. Greater than 70% of patients would consider rebiopsy after the procedure, if requested by their physician. Conclusions: We present a safe and effective method of LSGB for the diagnosis of SS. Level of Evidence: 4 Laryngoscope, 126:2041–2046, 2016.
AB - Objectives/Hypothesis: To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). Study Design: Prospective cohort study. Methods: Clinical data were prospectively obtained pre- and postbiopsy using patient-reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established criteria to determine the focus score. Data were analyzed using cross-tabulations. Results: Among the 58 patients in the study, 52 (90%) presented with sicca symptoms of dry eyes and/or mouth. Eight patients (14%) had histopathologic findings supportive of a diagnosis of SS. At 1 month postbiopsy, greater than 71% of patients denied any complaints of pain, swelling, numbness. or tingling. Sixteen patients (28%) had only a minor level of complaints. Only one patient complained of severe numbness at the biopsy site. Greater than 70% of patients would consider rebiopsy after the procedure, if requested by their physician. Conclusions: We present a safe and effective method of LSGB for the diagnosis of SS. Level of Evidence: 4 Laryngoscope, 126:2041–2046, 2016.
KW - Labial salivary gland biopsy
KW - sicca
KW - Sjögren's syndrome
UR - http://www.scopus.com/inward/record.url?scp=84983420649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983420649&partnerID=8YFLogxK
U2 - 10.1002/lary.25974
DO - 10.1002/lary.25974
M3 - Article
C2 - 27107215
AN - SCOPUS:84983420649
VL - 126
SP - 2041
EP - 2046
JO - Laryngoscope
JF - Laryngoscope
SN - 0023-852X
IS - 9
ER -